7570-49-2

Basic information

• Product Name: 5-AMINO-2-METHYLINDOLE
• Synonyms: 2-METHYL-1H-INDOL-5-AMINE;5-AMINO-2-METHYLINDOLE;5-AMINO-2-METHYLINDOL 97%;5-Amino-2-methylindole 95%;5-Amino-2-methylindole,95%;5-Amino-2-methylindole,98%;2-Methylindol-5-ylamine;5-Amino-2-methyl-1H-indole 95%
• CAS NO: 7570-49-2
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.19
• Product Categories: Indole;Indoles;Simple Indoles;Building Blocks;Heterocyclic Building Blocks;Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 7570-49-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 153-157 °C(lit.)
• Boiling Point: 255.81°C (rough estimate)
• Flash Point: 197.1 °C
• Appearance: brown crystalline powder or chunks
• Density: 1.0976 (rough estimate)
• Vapor Pressure: 2.76E-05mmHg at 25°C
• Refractive Index: 1.5600 (estimate)
• Storage Temp.: Freezer
• PKA: 17.97±0.30(Predicted)
• Sensitive: Stench
• CAS DataBase Reference: 5-AMINO-2-METHYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-METHYLINDOLE(7570-49-2)
• EPA Substance Registry System: 5-AMINO-2-METHYLINDOLE(7570-49-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 7570-49-2(Hazardous Substances Data)

Usage

Description

5-AMINO-2-METHYLINDOLE is a brown crystalline powder or chunks that serves as a versatile reactant in the synthesis of various compounds with diverse applications across different industries.

Uses

Used in Pharmaceutical Industry:
5-AMINO-2-METHYLINDOLE is used as a reactant for the preparation of cytotoxic and antimitotic agents, which are crucial in the development of treatments for cancer and other proliferative disorders.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 5-AMINO-2-METHYLINDOLE is utilized as a reactant for the synthesis of potential antimicrobial aminoketones, which can be used to combat bacterial and fungal infections.
Used in Neuropharmacology:
5-AMINO-2-METHYLINDOLE serves as a reactant in the preparation of inhibitors of monoamine oxidase (MAO), which are essential in the treatment of various psychiatric and neurological disorders.
Used in Cellular Signaling Research:
5-AMINO-2-METHYLINDOLE is used as a reactant for the synthesis of protein kinase C theta (PKCθ) inhibitors, which play a significant role in modulating cellular signaling pathways and have potential applications in the treatment of autoimmune diseases and cancers.
Used in Hematology:
5-AMINO-2-METHYLINDOLE is employed as a reactant in the preparation of Factor Xa inhibitors, which are vital in the development of anticoagulant drugs for the prevention and treatment of blood clot-related disorders.
Used in Angiogenesis Inhibition:
In the field of oncology, 5-AMINO-2-METHYLINDOLE is used as a reactant for the synthesis of inhibitors of vascular endothelial growth factor type 2 (VEGFR-2), which are crucial in the development of anti-angiogenic therapies to prevent the growth of new blood vessels in tumors.
Used in Natural Product Synthesis:
5-AMINO-2-METHYLINDOLE is utilized as a reactant in the preparation of demethylasterriquinone B1 receptor ligands, which are important in the study and development of novel bioactive natural products with potential applications in various therapeutic areas.
Used in Chemical Synthesis:
5-AMINO-2-METHYLINDOLE is a valuable reactant in the synthesis of a wide range of chemical compounds, making it an essential component in various chemical and pharmaceutical processes.

InChI:InChI=1/C9H10N2/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5,11H,10H2,1H3

Upstream product

• 7570-47-0 5-nitro-2-methylindole 
• 500730-27-8 N'-(3-acetyl-2-methyl-indol-5-yl)-N,N-dimethyl-sulfamide 
• 500730-25-6 N',N',N''',N'''-tetramethyl-N,N''-[(1-acetyl-2-oxo-propyl)-p-phenylene]-bis-sulfamide 
• 438187-37-2 2-(2-methoxy-2-propenyl)-N¹,N⁴-di[(E)-phenylmethylidene]-benzene-1,4-diamine 
• 6293-83-0 2-iodo-4-nitrophenylamine 
• 69951-01-5 2-iodo-1,4-phenylenediamine 
• 438187-35-0 2-iodo-N¹,N⁴-di[(E)-phenylmethylidene]-benzene-1,4-diamine 
• 115210-54-3 2-methyl-5-nitroindoline 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 865375-68-4 2,4-dichloro-N-(2-methyl-1H-indol-5-yl)-benzenesulfonamide 
• 1380422-93-4 10-(4-hydroxy-3-methoxyphenyl)-2-methyl-6,7,9,10-tetrahydro-1H-furo[3,4-b]pyrrolo[2,3-f]quinolin-9-one 
• 225382-63-8 [2-(3-Methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine 
• 871366-73-3 N-(2-methyl-1H-indol-5-yl)benzenesulfonamide 
• 1379535-60-0 (Z)-3-(2-methyl-1H-indole-5-ylamino)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1338222-19-7 N'-(1-{3-(2-chloro-6-fluoro-phenoxy)-2-[methoxyimino]-propyl}-2-methyl-1H-indol-5-yl)-N-ethyl-N-methyl-formamidine 
• 1338222-24-4 N'-[1-(2,4-dichloro-benzyl)-2-methyl-1H-indol-5-yl]-N-ethyl-N-methyl-formamidine 
• 1338223-17-8 N'-{1-[2-methoxyimino-3-(4-methoxy-phenoxy)-propyl]-2-methyl-1H-indol-5-yl}-N,N-dimethyl-acetamidine 
• 1338221-97-8 N'-{1-[2-methoxyimino-3-(3-trifluoromethyl-phenoxy)-propyl]-2-methyl-1H-indol-5-yl}-N,N-dimethyl-acetamidine 
• 1253057-41-8 N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide 

Relevant articles and documents

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Palladium nanoparticles stabilized by aqueous vesicles self-assembled from a PEGylated surfactant ionic liquid for the chemoselective reduction of nitroarenes

Vesicles self-assembled from an aqueous PEGylated surfactant ionic liquid solution can be applied for stabilizing palladium nanoparticles, which prove to be an efficient catalytic system for chemoselective hydrogen transfer of nitroarenes using hydrazine hydrate as a hydrogen source. The particle sizes of vesicles are decreased with the increase of ionic liquid's concentrations and relatively small particle sizes are beneficial to the reduction. Moreover, the aqueous catalytic system still stays in reactor by simple extraction, and is reused without further treatment.

Thienopyrimidine and thienopyridine derivatives useful as anticancer agents

The invention relates to compounds of the formulas 1 and 2 and to pharmaceutically acceptable salts and hydrates thereof, wherein X1, R1, R2and R11are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formulas 1 and 2 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formulas 1 and 2.