75715-21-8

Basic information

• Product Name: (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione
• Synonyms: (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione
• CAS NO: 75715-21-8
• Molecular Weight: 253.301
• Mol File: 75715-21-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione(75715-21-8)
• EPA Substance Registry System: (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione(75715-21-8)

Safety Data

• Hazardous Substances Data: 75715-21-8(Hazardous Substances Data)

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 100-46-9 benzylamine 
• 129-64-6 3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride 
• 100-39-0 benzyl bromide 
• 6265-30-1 (1R,2S,6R,7S)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione 
• 1251910-89-0 C₁₇H₁₃NO₂ 
• 108-31-6 maleic anhydride 
• 100-44-7 benzyl chloride 
• 106754-07-8 endo-3-(N-benzylcarbamoyl)bicyclo[2.2.1]hept-5-ene-endo-2-carboxylic acid 

Downstream Products

• 171897-52-2 2-benzyl-1,3,r-3a,4,7,c-7a-hexahydro-t-4,t-7-methanoisoindole 
• 21449-84-3 2-benzyl-5c,6c-epoxy-(3ac,7ac)-hexahydro-4r,7c-methano-isoindole-1,3-dione 

Relevant articles and documents

Synthesis of novel fluorinated building blocks via halofluorination and related reactions

A study exploring halofluorination and fluoroselenation of some cyclic olefins, such as diesters, imides, and lactams with varied functionalization patterns and different structural architectures is described. The synthetic methodologies were based on electrophilic activation through halonium ions of the ring olefin bonds, followed by nucleophilic fluorination with Deoxo-Fluor. The fluorine-containing products thus obtained were subjected to elimination reactions, yielding various fluorine-containing small-molecular entities.

Synthesis of 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as lead scaffolds for neuroprotective agents

Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, a polycyclic cage amine, and tricyclo[6.2.1.02,7]undec-9-ene-3,6-dione have been shown to display calcium-modulating properties. In this study, we synthesised structurally-related 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione as the base scaffold, and incorporated various functional moieties through aminolysis, to afford a series of imide derivatives. All final compounds were obtained in yields between 47-97% and their structures were confirmed by NMR, IR and MS. These structurally-related derivatives could potentially act as neuroprotective agents. Additionally, their synthetic versatilities could make them precursors, as lead compounds, to potential pharmacologically-active agents.

Mechanochemical Grinding Diels-Alder Reaction: Highly Efficient and Rapid Access to Bi-, Tri-, and Tetracyclic Systems

Grinding of various electron-deficient dienophiles with diverse dienes in a pestle and mortar for 1-15 minutes afforded the corresponding Diels-Alder adducts in quantitative yields under catalyst-free and solvent-free conditions, without the necessity for