757247-99-7

Basic information

• Product Name: 4-Amino-3-Fluoro-2-Chlorobenzonitrile
• Synonyms: 4-Amino-3-Fluoro-2-Chlorobenzonitrile;4-AMINO-2-CHLORO-3-FLUOROBENZONITRILE
• CAS NO: 757247-99-7
• Molecular Formula: C₇H₄ClFN₂
• Molecular Weight: 170.5715
• Product Categories: Fluorine series
• Mol File: 757247-99-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 320℃
• Flash Point: 147℃
• Appearance: /
• Density: 1.42
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.73±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3-Fluoro-2-Chlorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-Fluoro-2-Chlorobenzonitrile(757247-99-7)
• EPA Substance Registry System: 4-Amino-3-Fluoro-2-Chlorobenzonitrile(757247-99-7)

Safety Data

• Hazardous Substances Data: 757247-99-7(Hazardous Substances Data)

Usage

General Description

4-Amino-3-Fluoro-2-Chlorobenzonitrile, also known as 4-Amino-3-Fluoro-2-Chlorobenzonitrile, is a chemical compound with the molecular formula C7H4ClFN2. It is a white to beige crystalline solid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-Amino-3-Fluoro-2-Chlorobenzonitrile is utilized in the production of various drugs, including anti-cancer and anti-inflammatory medications. It is important to handle 4-Amino-3-Fluoro-2-Chlorobenzonitrile with care as it is classified as a hazardous material and should be stored and handled according to safety guidelines.

InChI:InChI=1/C7H4ClFN2/c8-6-4(3-10)1-2-5(11)7(6)9/h1-2H,11H2

Upstream product

• 115843-99-7 4-bromo-3-chloro-2-fluoroaniline 
• 757247-98-6 4-amino-2-chloro-3-fluoro-benzaldehyde 
• 395-36-8 N-(3-chloro-2-fluorophenyl)acetamide 
• 143360-05-8 N-(4-bromo-3-chloro-2-fluorophenyl)acetamide 

Downstream Products

• 864271-01-2 4-isocyanato-3-fluoro-2-chlorobenzonitrile 
• 1272719-26-2 C₈H₂ClFN₂S 
• 1272718-97-4 4-[7-(3-chloro-4-cyano-2-fluoro-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide 
• 1272718-99-6 4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-2-fluoro-N-methyl-benzamide 
• 1272719-04-6 2-chloro-3-fluoro-4-[3-(4-methanesulfonyl-phenyl)-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-benzonitrile 
• 1272719-05-7 2-chloro-4-[4,4-dimethyl-3-(6-methyl-pyridin-3-yl)-5-oxo-2-thioxo-imidazolidin-1-yl]-3-fluoro-benzonitrile 
• 1272719-06-8 4-(4,4-dimethyl-5-oxo-2-thioxo-3-p-cyanophenyl-imidazolidin-1-yl)-3-fluoro-2-chloro-benzonitrile 
• 1272719-15-9 2-chloro-4-(4,4-dimethyl-5-oxo-2-thioxo-3-p-tolyl-imidazolidin-1-yl)-3-fluoro-benzonitrile 
• 1272719-17-1 2-chloro-3-fluoro-4-[3-(3-fluoro-4-methyl-phenyl)-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-benzonitrile 
• 1124214-23-8 N-tert-butyl-3-((4-(2-chloro-4-(3-(cyclopropylmethyl)ureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)benzamide 
• 1124214-28-3 3-((4-(4-amino-2-chloro-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide 
• 1398045-47-0 C₂₆H₂₆ClFN₄O₂S 
• 1398045-41-4 4-{4-[3-(3-chloro-4-cyano-2-fluoro-phenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]-phenyl}-2,2,N-trimethyl-butyramide 
• 1398045-33-4 2-chloro-3-fluoro-4-(3-{4-[3-(1H-imidazol-2-yl)-propyl]-phenyl}-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl)-benzonitrile 

Relevant articles and documents

ISOQUINOLINE COMPOUNDS AND USES THEREOF

Isoquinoline compounds of formula (I) variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

8-AMINOISOQUINOLINE CompoundS AND USES THEREOF

3-Carbonylamino-8-aminoisoquinoline Compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The Compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline Compounds.

INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE

Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, methods for use as Bruton's tyrosine kinase and methods of production.