757967-68-3Relevant articles and documents
Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties
Miyazaki, Anna,Tsuda, Yuko,Fukushima, Shoji,Yokoi, Toshio,Vántus, Tibor,B?k?nyi, Gy?ngyi,Szabó, Edit,Horváth, Anikó,Kéri, Gy?rgy,Okada, Yoshio
supporting information; experimental part, p. 5121 - 5124 (2009/08/07)
On the basis of the structure of somatostatin analogue TT-232 (1), which exhibited a highly potent antitumor activity, we synthesized small linear peptide derivatives and evaluated their antitumor and apoptotic activity. Of them, Boc-Tyr-D-Trp-1-adamantylamide (5) had the most potent cell antiproliferative activity in SW480 and A431 cell lines, which was supported in A431 cell lines by FACS analysis that demonstrated a major increase in DNA fragmentation in the subG1 fraction.
Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells
Miyazaki, Anna,Yokoi, Toshio,Tachibana, Yoshifumi,Enomoto, Riyo,Lee, Eibai,Bokonyi, Gyongyi,Keri, Gyorgy,Tsuda, Yuko,Okada, Yoshio
, p. 6323 - 6327 (2007/10/03)
It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp- Lys-Cys)-Thr-NH2, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.
