75806-98-3Relevant articles and documents
4-Methoxy-2,6-dimethylbenzenesulphonyl (Mds): a New Protecting Group of the Guanidino Function in Peptide Synthesis
Fujino, Masahiko,Nishimura, Osamu,Wakimasu, Mitsuhiro,Kitada, Chieko
, p. 668 - 669 (2007/10/02)
The 4-methoxy-2,6-dimethylbenzenesulphonyl (Mds) group for the protection of the guanidino function, which is readily removed with trifluoroacetic acid-thioanisole but is resistant to hydrogenolysis or treatment with dilute hydrogen chloride, can be used in the solution synthesis of arginine-containing peptides; this protecting group was effectively used in the synthesis of substance P and two LH-RH analogues.