75808-01-4 Usage
Description
3-Hydroxy-7-oxocholanoyltaurine, also known as 7-Ketolithocholic Acid-taurine Conjugate, is a bile acid conjugate and metabolite of Taurolithocholic Acid (T009100). It possesses anti-inflammatory properties and has been shown to play a role in inhibiting hepatocyte apoptosis through the suppression of Bid translocation to mitochondria.
Uses
Used in Pharmaceutical Industry:
3-Hydroxy-7-oxocholanoyltaurine is used as an anti-inflammatory agent for its ability to modulate inflammatory responses and potentially alleviate inflammation-related conditions.
Used in Hepatoprotective Applications:
In the pharmaceutical industry, 3-hydroxy-7-oxocholanoyltaurine is also used as a hepatoprotective agent, particularly for its demonstrated ability to inhibit hepatocyte apoptosis and protect liver cells from damage.
Used in Research and Development:
3-Hydroxy-7-oxocholanoyltaurine serves as a valuable compound in the field of research and development, where it can be utilized to study the mechanisms of bile acid metabolism, inflammation, and liver cell protection. This knowledge can contribute to the development of novel therapeutic strategies for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 75808-01-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,8,0 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 75808-01:
(7*7)+(6*5)+(5*8)+(4*0)+(3*8)+(2*0)+(1*1)=144
144 % 10 = 4
So 75808-01-4 is a valid CAS Registry Number.
InChI:InChI=1/C26H43NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-21,24,28H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,24?,25+,26-/m1/s1
75808-01-4Relevant articles and documents
Synthetic method of tauroursodeoxycholic acid
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Page/Page column 6-11, (2019/03/17)
The invention discloses a synthetic method of tauroursodeoxycholic acid. The synthetic method comprises the following steps: taking extracted or synthetic taurochenodeoxycholic acid as a raw material,obtaining a target product tauroursodeoxycholic acid crude product through 7 alpha-hydroxyl selective oxidation, 3 alpha-hydroxyl protection, 7-carbonyl selective oxidation, 7 alpha-hydroxyl sulfonylation, detosylation and alkaline hydrolysis reactions of the taurochenodeoxycholic acid, and finally obtaining the high-purity tauroursodeoxycholic acid through recrystallization purification. The tauroursodeoxycholic acid is obtained by using low-cost poultry bile as the raw material, the traditional steps of hydrolyzing and then condensing combined chenodeoxycholic acid are omitted, and a taurylamine structure is obtained directly; the target configuration product is obtained through selective oxidation, selective reduction and stereoselectivity elimination; in the whole technology, using high alkali, metallic sodium or valuable catalysts is avoided, and the whole technology presents a relatively efficient and safe chemical synthetic route. The technological process has the advantages ofbeing simple and controllable, high in purity, efficient, safe, environmentally-friendly and easy for industrialization, and has good application prospects in the field of pharmacy.
