75815-53-1

Basic information

• Product Name: 1H-Imidazole-4-carboxylic acid, 5-methyl-1-(phenylmethyl)-, ethyl ester
• CAS NO: 75815-53-1
• Molecular Formula: C14H16N2O2
• Molecular Weight: 244.293
• Mol File: 75815-53-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-4-carboxylic acid, 5-methyl-1-(phenylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4-carboxylic acid, 5-methyl-1-(phenylmethyl)-, ethyl ester(75815-53-1)
• EPA Substance Registry System: 1H-Imidazole-4-carboxylic acid, 5-methyl-1-(phenylmethyl)-, ethyl ester(75815-53-1)

Safety Data

• Hazardous Substances Data: 75815-53-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 51605-32-4 ethyl 4⁽⁵⁾-methylimidazole-5⁽⁴⁾-carboxylate 
• 51605-32-4 Ethyl 5-Methyl-4-imidazolecarboxylate 

Downstream Products

• 120231-11-0 1-<5-methyl-1-(phenylmethyl)-1H-imidazol-4-yl>propan-2-one 
• 120231-13-2 α-amino-α,5-dimethyl-1-(phenylmethyl)-1H-imidazole-4-propanoic acid 
• 120231-09-6 1-<5-methyl-1-(phenylmethyl)-1H-imidazol-4-yl>-2-nitropropene 
• 120231-12-1 1-<5-methyl-1-(phenylmethyl)-1H-imidazol-4-yl>propan-2-one oxime 
• 120231-06-3 2-<5-methyl-1-(phenylmethyl)-1H-imidazol-4-yl>-1-nitroethene 
• 120231-07-4 2-<5-methyl-1-(phenylmethyl)-1H-imidazol-4-yl>ethanone oxime 
• 120231-08-5 2-<5-methyl-1-(phenylmethyl)-1H-imidazol-4-yl>ethanamine 
• 75815-57-5 5-methyl-1-(phenylmethyl)-1H-imidazole-4-carboxaldehyde 
• 36376-47-3 2-<5-methyl-1H-imidazol-4-yl>ethanamine dihydrochloride 
• 108418-74-2 7,8-dihydro-1-methyl-8-oxo-6-phenyl-2-(phenylmethyl)imidazo<1,5-a>pyrazinium bromide 
• 108418-75-3 5,6-dihydro-1-methyl-6-phenylimidazo<1,5-a>pyrazin-8(7H)-one 
• 108418-76-4 1-methyl-6-phenylimidazo<1,5-a>pyrazin-8(7H)-one 
• 108418-73-1 5-methyl-1-(phenylmethyl)-1H-imidazole-4-carboxamide 
• 75815-55-3 5-methyl-1-(phenylmethyl)-1H-imidazole-4-methanol 

Relevant articles and documents

Regioselective alkylation of 2-alkyl-5,6,7,8-tetrahydro-3H- cycloheptimidazol-4-ones and 2-alkyl-3H-cycloheptimidazol-4-ones

Regioselective alkylation of 2-alkyl-5,6,7,8-tetrahydro-3H- cycloheptimidazol-4-one (1) and 2-alkyl-3H-cycloheptimidazol-4-one (2) was investigated. 3-[2′-(1-tert-Butyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-2- propyl-5,6,7,8-tetrahydro-1H-cycloheptimidazol-4-one (6) was preferentially obtained under the conditions by using NaH in DMF or THF. On the other hand, 3-[2′-(1-tert-butyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-2-propyl-5,6,7, 8-tetrahydro-3H-cycloheptimidazol-4-one (5), the synthetic intermediate compound of Pratosartan, was obtained selectively in the presence of n-Bu4NBr in toluene by using aqueous sodium hydroxide as a base. In this reaction, it was found that the concentration of the alkaline solution influences its regioselectivity. This selectivity was observed even for aldehyde and ester derivatives.

Synthesis of 6-phenylimidazo[1,2-a]pyrazin-8-one and 1-methyl-6-phenylimidazo[1,5-a]pyrazin-8-one via quaternary intermediates

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