75816-16-9

Basic information

• Product Name: N^α-acetyl-5-bromo-D-tryptophan
• Synonyms: N^α-acetyl-5-bromo-D-tryptophan
• CAS NO: 75816-16-9
• Molecular Weight: 325.162
• Mol File: 75816-16-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 124-127 °C
• Boiling Point: 627.7±55.0 °C(Predicted)
• Density: 1.615±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N^α-acetyl-5-bromo-D-tryptophan(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-acetyl-5-bromo-D-tryptophan(75816-16-9)
• EPA Substance Registry System: N^α-acetyl-5-bromo-D-tryptophan(75816-16-9)

Safety Data

• Hazardous Substances Data: 75816-16-9(Hazardous Substances Data)

Upstream product

• 75816-15-8 N^α-acetyl-5-bromo-D,L-tryptophan 

Downstream Products

• 108827-09-4 Bpoc-Asn-Phe-Phe-D-Thr(Br)-OH 

Relevant articles and documents

Synthesis of tripeptides containing d-Trp substituted at the indole ring, assessment of opioid receptor binding and in vivo central antinociception

The noncationizable tripeptide Ac-d-Trp-Phe-GlyNH2 was recently proposed as a novel minimal recognition motif for μ-opioid receptor. The introduction of different substituents (methyl, halogens, nitro, etc.) at the indole of d-Trp significantly influenced receptor affinities and resulted in serum stability and in a measurable effect on central antinociception in mice after ip administration.

Synthesis of 5- and 7-Bromotryptophan and of 9>-β-corticotrophin-(1-24)-tetracosapeptide, a Highly Potent Corticotrophin Analogue

The synthesis of 5- and 7-bromo-L-tryptophans via Fischer cyclisation of the appropriate bromophenylhydrazone of 4-acetamido-4,4-bis(ethoxycarbonyl)butanal is described.The title tetracosapeptide was synthesised using standard methods of stepwise and fragment condensation.The product was pure as judged by amino-acid analysis after acidic or enzymic hydrolysis and by high pressure liquid chromatography.In an isolated adrenal cell bioassay, the peptide had a steroidogenic potency 2.4 times that of Synacthen.