75887-54-6 Usage
Description
Arteether is a sesquiterpene acetal with an endoperoxide bridge, which is an ether derivative of the naturally occurring compound artemisinin. It is a white crystalline solid that has been used as an effective treatment for severe malaria infections, particularly in children and adolescents. Arteether acts rapidly against Plasmodium, the parasite responsible for malaria, during the early blood stage of its development and exhibits gametocytocidal activity against Plasmodium falciparum, reducing its potential for transmission.
Uses
Used in Antimalarial Applications:
Arteether is used as an antimalarial drug for the treatment of severe malaria infections in children and adolescents. It is administered by intramuscular injection in a solution of sesame oil. The drug is efficient, rapidly acting, and well-tolerated, with a mean parasite clearance time of approximately 38 hours.
Used in Combination Therapy:
Arteether is also used in combination with other long-lived antimalarials, such as mefloquine or pyrimethamine/sulfa, to enhance the regression of malaria. This combination therapy aims to improve the overall effectiveness of the treatment and reduce the potential for drug resistance.
Used in Pharmaceutical Industry:
Arteether, under the brand name Artemotil, is used as a key component in the development of new antimalarial drugs and drug formulations. Its rapid action and gametocytocidal properties make it a valuable asset in the fight against malaria, particularly in regions where the disease is prevalent.
Check Digit Verification of cas no
The CAS Registry Mumber 75887-54-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,8,8 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75887-54:
(7*7)+(6*5)+(5*8)+(4*8)+(3*7)+(2*5)+(1*4)=186
186 % 10 = 6
So 75887-54-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14?,15-,16-,17-/m1/s1
75887-54-6Relevant articles and documents
Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
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, (2015/02/02)
The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.
New method for the synthesis of ether derivatives of artemisinin
Bora, Pranjal P.,Baruah, Nabajyoti,Bez, Ghanashyam,Barua, Nabin C.
, p. 1218 - 1225 (2012/04/04)
Dihydroartemisinin can be converted to its ether derivatives in good yields by reaction with different alcohols in the presence of a catalytic amount of dodecatungstophosphoric acid hydrate. Easy handling, trouble-free workup by filtration, excellent yields, and very short reaction times are some of the highlights of this protocol. Copyright Taylor & Francis Group, LLC.
PREPARATIVE PROCESS FOR ETHER DERIVATIVE OF ARTEMISININ
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Page/Page column 11; 12; 14; 15, (2008/12/07)
The present invention relates to a process for synthesis of ether derivative of artemisinin by reducing artemisinin to dihydroartemisinin using a mixture of sodium borohydride and a dihydroxy compound, followed by etherification in presence of an acid catalyst and an alcohol.