75898-26-9Relevant articles and documents
2-AZA-?-ALLYLPALLADIUM COMPLEXES FOR THE SYNTHESIS OF β-CARBOXYASPARTIC ACID (ASA) DERIVATIVES
O'Donnell, Martin J.,Yang, Xiaobei,Li, Min
, p. 5135 - 5138 (2007/10/02)
Reaction of malonate anions with Schiff base acetates (3) in the presence of a palladium catalyst yields protected derivatives of β-carboxyaspartic acid (5).
SYNTHESIS OF D,L-β-CARBOXYASPARTIC ACID FROM HYDANTOIN-5-MALONIC ACID DIETHYL ESTER
Henson, Edward B.,Gallop, Paul M.,Hauschka, Peter V.
, p. 2561 - 2562 (2007/10/02)
Hydantoin-5-malonic acid diethyl ester was synthesized by reduction of parabanic acid (oxalyl urea) to 5-hydroxy-hydantoin, conversion to 5-chlorohydantoin and condensation with malonic ester.Alkaline hydrolysis gave D,L-β-carboxyaspartic acid.