759-02-4Relevant articles and documents
C-F Bond Activation of a Perfluorinated Ligand Leading to Nucleophilic Fluorination of an Organic Electrophile
Hanson-Heine, Magnus W. D.,Licence, Peter,Marr, Andrew C.,Morgan, Patrick J.,Saunders, Graham C.,Thomas, Hayden P.
supporting information, p. 2116 - 2124 (2020/07/23)
We report a fluorine transfer reaction in which fluorine from a perfluorinated ligand undergoes C-F bond activation and transfers to an electrophile, resulting in the formation of a new fluorinated product and dimerization of the monodefluorinated complex. Treatment of [(η5,κ2C-C5Me4CH2C6F5CH2NC3H2NMe)-RhCl] with the organic electrophile, toluoyl chloride, resulted in the formation of a rhodium(III) metallocycle via C-F bond activation assisted defluorinative coupling. Fission of the C-F bond liberated nucleophilic fluoride, which converted acyl chloride to acyl fluoride. The overall reaction was monitored using a multivariate analysis approach in real time.
One-pot fluorination and Mannich reactions of 1,3-dicarbonyl compounds
Pham, Kenny,Huang, Xin,Zhang, Wei
supporting information, p. 1998 - 2000 (2015/03/18)
Abstract One-pot fluorination of 1,3-dicarbonyl compounds with Selectfluor followed by the Mannich reaction with anilines and benzaldehydes is developed for the synthesis of α-fluoro and aminomethylated 1,3-dicarbonyl compounds.
One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds
Yi, Wen-Bin,Cai, Chun,Huang, Xin,Zhang, Wei
, p. 3185 - 3189,5 (2020/09/16)
Fluorination followed by the Michael addition or Robinson annulation of 1,3-dicarbonyl compounds is introduced for the synthesis of acyclic and cyclic α-fluoro-β-ketoesters and α-fluoro-1,3-diketones. The decarboxylation step can also be added to the reac