75920-45-5

Basic information

• Product Name: (+/-)-2-(4'-methylphenyl)-propionitrile
• Synonyms: (+/-)-2-(4'-methylphenyl)-propionitrile
• CAS NO: 75920-45-5
• Molecular Weight: 145.204
• Mol File: 75920-45-5.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: (+/-)-2-(4'-methylphenyl)-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-2-(4'-methylphenyl)-propionitrile(75920-45-5)
• EPA Substance Registry System: (+/-)-2-(4'-methylphenyl)-propionitrile(75920-45-5)

Safety Data

• Hazardous Substances Data: 75920-45-5(Hazardous Substances Data)

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 74-88-4 methyl iodide 
• 149-73-5 trimethyl orthoformate 
• 122-00-9 para-methylacetophenone 
• 106-38-7 para-bromotoluene 
• 1266802-94-1 potassium 2-cyanopropanoate 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 67-56-1 methanol 
• 77287-34-4 formamide 
• 766-97-2 4-n-methylphenylacetylene 
• 557-21-1 zinc(II) cyanide 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 124-38-9 carbon dioxide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 171779-51-4 2-Methyl-2-(4-methylphenyl)-5-bromo-5-hexen-1-al 
• 938-94-3 (R,S)-2-(4'-methylphenyl) propionic acid 
• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 
• 1372209-58-9 N-methyl-2-(p-tolyl)propanamide 

Relevant articles and documents

A convenient reductive removal of benzylic hydroxyl and trimethylsilyloxyl groups with Me3SiCl-NaI-MeCN reagent

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Nickel/Cobalt-Catalyzed Reductive Hydrocyanation of Alkynes with Formamide as the Cyano Source, Dehydrant, Reductant, and Solvent

A Ni/Co co-catalyzed reductive hydrocyanation of various alkynes was developed for the production of saturated nitriles. Hydrocyanic acid is generated in situ from safe and readily available formamide. Formamide played multiple roles as a cyano source, dehydrant, and reductant for the NiII pre-catalyst and vinyl nitriles, along with acting as the co-solvent in this reaction. Detailed mechanistic investigation supported a pathway via hydrocyanation of C≡C bond and the subsequent reduction of C=C bond. Wide substrate scope, the employment of a cheap and stable nickel salt as pre-catalyst, a safe cyano source and convenient experimental operation render this hydrocyanation practical for the laboratory synthesis of saturated nitriles. (Figure presented.).

Preparation method of alkyl nitrile compound

The invention discloses a preparation method of an alkyl nitrile compound. Specifically, the preparation method comprises the following step: in an organic solvent, in the presence of a protective gasand under the action of a catalyst, carrying out a reduction reaction as shown in the specification on olefin as shown in a formula I, a cyanation reagent and water, wherein the alkyl nitrile compound 1 is a compound II and/or a compound III. The preparation method provided by the invention is mild in condition, can realize hydrocyanation of olefin more safely and efficiently, and has good substrate universality and functional group compatibility.