75948-77-5

Basic information

• Product Name: 4,6-DIMETHYLINDOLE
• Synonyms: 4,6-DIMETHYLINDOLE;4,6-diMethyl-1H-indole;1H-Indole, 4,6-diMethyl-
• CAS NO: 75948-77-5
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• EINECS: 200-258-5
• Mol File: 75948-77-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 275.282 °C at 760 mmHg
• Flash Point: 115.996 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• PKA: 17.72±0.30(Predicted)
• CAS DataBase Reference: 4,6-DIMETHYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIMETHYLINDOLE(75948-77-5)
• EPA Substance Registry System: 4,6-DIMETHYLINDOLE(75948-77-5)

Safety Data

• Hazardous Substances Data: 75948-77-5(Hazardous Substances Data)

Usage

General Description

4,6-DIMETHYLINDOLE is a chemical compound with the molecular formula C10H11N. It is an indole derivative that contains two methyl groups attached to the 4 and 6 positions of the indole ring. It is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. 4,6-DIMETHYLINDOLE has been studied for its potential biological activities, including its anticancer, antioxidant, and anti-inflammatory properties. It is also used as a dye intermediate and in the production of synthetic perfumes. However, it is important to handle 4,6-DIMETHYLINDOLE with care, as it may cause skin and eye irritation and is toxic if ingested or inhaled.

InChI:InChI=1/C10H11N/c1-7-5-8(2)9-3-4-11-10(9)6-7/h3-6,11H,1-2H3

Upstream product

• 107-21-1 ethylene glycol 
• 108-69-0 3,5-dimethylaminoaniline 

Downstream Products

• 178469-71-1 N-(4,6-dimethyl-1-pentylindolin-7-yl)-2,2-dimethylpropanamide 

Relevant articles and documents

β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction

Borrowing Hydrogen (BH), also called Hydrogen Autotransfer (HA), reaction with neat ethylene glycol represents a key step in the preparation of β-amino alcohols. However, due to the stability of ethylene glycol, mono-activation has rarely been achieved. Herein, a combination of Pd/C and ZnO is reported as heterogeneous catalyst for this BH/HA reaction. This system results in an extremely air and moisture stable, and economic catalyst able to mono-functionalize ethylene glycol in water, without further activation of the diol. In this work, different diols and aromatic amines have been explored affording a new approach towards amino alcohols. This study reveals how the combination of two solid species can afford interesting catalytic properties in heterogeneous phase. ZnO activates ethylene glycol while Pd/C is the responsible of the BH/HA cycle. This catalytic system has also been found useful to dehydrogenate indoles affording indolines that undergo in situ BH/HA cycle prior to re-aromatization, representing a tandem heterogeneous process.