75996-92-8Relevant articles and documents
Reactions of 4,5-Dihydro-5-methylpyranoindole-1,3-dione; a Synthesis of N-Methylisotryptophol
Bahadur, Gulam A.,Baylei, A. Sydney,Middleton, Nigel W.,Peach, Josephine M.
, p. 1688 - 1692 (2007/10/02)
Boiling 4,5-dihydro-5-methylpyranoindole-1,3-dione (7) with alcohols followed by decarboxylation of the half-esters so formed leads to esters of 1-methylindol-2-ylacetic acid; reduction of these esters then affords N-methylisotryptophol (10).Reaction of 3-carboxy-1-methylindol-2-ylacetic acid (6; R=H) with acetic acid-sodium acetate gives 3,5-dimethylpyranoindol-1(5H)-one (17); with dimethylformamide-phosphorus oxychloride, 4-(NN-dimethylaminomethylene)-4,5-dihydro-5-methylpyranoindole-1,3-dione (22) was obtained.