76-72-2Relevant articles and documents
High-purity 5-ethyl-5-(1-methylbutyl)barbituric acid preparation method
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Paragraph 0021; 0023; 0025; 0027; 0029; 0031; 0033; 0035, (2019/10/04)
The present invention relates to a preparation method of a drug pentobarbital (1) for sedation, hypnosis, pre-anesthesia administration and anti-convulsion, and provides a new preparation process for preparing high-purity pentobarbital (I) from diethyl ethylmalonate, wherein the process comprises three steps: A, bromination; B, alkylation; and C, cyclization, acidification, and purification. According to the present invention, the method has advantages of simple operation, short production cycle, low energy consumption, mother liquor circulation, less three-waste, stable process, good product quality, high product purity, isomer impurity content of less than 0.1%, high yield and low production cost, and is suitable for industrial production.
Alkylation of Monosubstituted Malonate Anions With Pyridinium and Quinolinium Salts
Katritzky, Alan R.,Aurrecoechea, Jose M.
, p. 342 - 345 (2007/10/02)
Monosubstituted malonate anions are alkylated at room temperature with 1-(sec-alkyl)quinolinium salts.Hindered disubstituted malonate esters can thus be prepared under very mild conditions.