76098-72-1Relevant articles and documents
The von Braun Reaction Applied to Azetidines
Wright, Karen,Drouillat, Bruno,Menguy, Laurence,Marrot, Jér?me,Couty, Fran?ois
, p. 7195 - 7201 (2017)
The von Braun reaction (the reaction of cyanogen bromide with tertiary amines) was applied to a series of functionalized N-alkyl-substituted azetidines. This reaction mainly led to the cleavage of the strained four-membered ring to produce 3-bromo N-alkyl cyanamides in good yields with variable regioselectivity. The resulting cyanamide products were then employed as original building blocks for the synthesis of nitrogen heterocycles.
