76105-84-5

Basic information

• Product Name: Pyridine, 4-isothiocyanato- (9CI)
• Synonyms: Pyridine, 4-isothiocyanato- (9CI);4-Pyridyl isothiocyanate
• CAS NO: 76105-84-5
• Molecular Formula: C₆H₄N₂S
• Molecular Weight: 136.17436
• Product Categories: PYRIDINE
• Mol File: 76105-84-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 253.806°C at 760 mmHg
• Flash Point: 107.298°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0.029mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: Pyridine, 4-isothiocyanato- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-isothiocyanato- (9CI)(76105-84-5)
• EPA Substance Registry System: Pyridine, 4-isothiocyanato- (9CI)(76105-84-5)

Safety Data

• Hazardous Substances Data: 76105-84-5(Hazardous Substances Data)

Usage

General Description

Pyridine, 4-isothiocyanato- (9CI) is a chemical compound with the molecular formula C6H4N2S. It is a derivative of pyridine, a heterocyclic compound commonly used as a solvent and reagent in organic synthesis. The isothiocyanate group (-N=C=S) is known for its ability to react with amine and thiol compounds, making 4-isothiocyanato-pyridine useful in the production of various pharmaceuticals, agrochemicals, and fine chemicals. It is also used in the synthesis of other heterocyclic compounds and as a ligand in coordination chemistry. The compound has potential applications in the pharmaceutical industry and in materials science due to its unique chemical properties and reactivity. However, it is important to handle it with care and ensure proper safety measures are in place when working with this chemical.

InChI:InChI=1/C6H4N2S/c9-5-8-6-1-3-7-4-2-6/h1-4H

Upstream product

• 45810-08-0 4-pyridyldithiocarbamic acid zwitterion 
• 504-24-5 4-aminopyridine 
• 463-71-8 thiophosgene 
• 102368-13-8 1,1'-Thiocarbonyldi-2(1H)-pyridone 
• 96989-50-3 di-2-pyridyl thionocarbonate 
• 143896-65-5 N-Phenylbenzimidchlorid 

Downstream Products

• 372096-20-3 N-[4-[(pyridin-4-yl)aminothiocarbonylamino]phenyl]-(2-chloro-5-nitrophenyl)carboxamide 
• 372096-19-0 N-[4-[4-[(pyridin-4-yl)aminothiocarbonylamino]phenyl]phenyl]-(2-chloro-5-nitrophenyl)carboxamide 
• 1258218-33-5 N-(benzyloxy)-N-(8-(3-pyridin-4-ylthioureido)octyl)propane-2-sulfonamide 
• 39536-03-3 N-(phenylcarbamothioyl)benzenecarboximidamide 
• 321689-96-7 1-allyl-3-(pyridin-4-yl)thiourea 
• 1289638-25-0 C₁₆H₁₄N₄O₂S 
• 1289638-24-9 C₁₆H₁₄N₄O₂S 
• 1289638-23-8 C₁₆H₁₄N₄O₂S 
• 1289638-22-7 C₁₅H₁₁FN₄OS 
• 1289638-21-6 C₁₅H₁₁FN₄OS 
• 1289638-20-5 C₁₅H₁₁FN₄OS 
• 1027262-54-9 Diethyl-[2-(1-pyridin-4-yl-1,4,5,6-tetrahydro-cyclopentaimidazol-2-ylsulfanylmethyl)-phenyl]-amine 
• 900525-38-4 2-cyano-2-(pyridin-4-ylthiocarbamoyl)-thioacetimidic acid 2,4,6-trimethoxy-benzyl ester 
• 60572-66-9 N-benzyl-N'-4-pyridylthiourea 

Relevant articles and documents

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea against Meloidogyne incognita

Two series of novel 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea were designed and synthesized. The bioassay results showed that most of the test compounds showed good nematicidal activity against M. incognita at the concentration of 10.0?mg?L?1 in vivo. The compounds A13, A17 and B3 showed excellent nematicidal activity on the second stage juveniles of the root-knot nematode with the inhibition rate of 51.3%, 58.3% and 51.3% at the concentration of 1.0?mg?L?1 respectively. It suggested that the structure of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea could be optimized further.

TRIAZOLE AGONISTS OF THE APJ RECEPTOR

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.

A METHOD OF INHIBITING TAU PHOSPHORYLATION

A method of inhibiting phosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in recognized need thereof such as cells of the central nervous system an effective amount of a of a compound or a pharmaceutically acceptable salt thereof that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1, and contains at least four of the six pharmacophores of FIGS. 35-40.