76196-79-7

Basic information

• Product Name: 2-CYANO-5-ETHOXYCARBONYLPYRIDINE
• Synonyms: 6-Cyano-3-pyridinecarboxylic acid ethyl ester;6-Cyanonicotinic acid ethyl ester;3-Pyridinecarboxylic acid, 6-cyano-, ethyl ester;5-ethoxycarbonyl-2-pyridinecarbonitrile
• CAS NO: 76196-79-7
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Mol File: 76196-79-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 56-57℃
• Boiling Point: 125 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.21
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.25±0.10(Predicted)
• CAS DataBase Reference: 2-CYANO-5-ETHOXYCARBONYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-5-ETHOXYCARBONYLPYRIDINE(76196-79-7)
• EPA Substance Registry System: 2-CYANO-5-ETHOXYCARBONYLPYRIDINE(76196-79-7)

Safety Data

• Hazardous Substances Data: 76196-79-7(Hazardous Substances Data)

Usage

General Description

2-CYANO-5-ETHOXYCARBONYLPYRIDINE is a chemical compound with the molecular formula C10H8N2O2. It is a pyridine derivative with a cyano group and an ethoxycarbonyl group attached to the 2 and 5 positions, respectively. 2-CYANO-5-ETHOXYCARBONYLPYRIDINE is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a pale yellow solid with a molecular weight of 192.18 g/mol. 2-CYANO-5-ETHOXYCARBONYLPYRIDINE has the potential to act as a nucleophilic catalyst in various chemical reactions due to the presence of the electron-withdrawing cyano group. Furthermore, it is an important building block in organic chemistry, providing a versatile starting material for the synthesis of diverse compounds.

Upstream product

• 151-50-8 potassium cyanide 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 145432-77-5 3-ethoxycarbonyl-1-methoxy-pyridinium; methyl sulfate 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 14906-63-9 1-oxy-nicotinic acid ethyl ester 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 1446321-37-4 2-(imidazo[1,5-a]pyridin-6-ylmethoxy)-5-methoxybenzaldehyde 
• 1189434-55-6 ethyl 6-(aminomethyl)-3-pyridinecarboxylate hydrochloride 
• 256935-75-8 ethyl imidazo[1,5-a]pyridine-6-carboxylate 

Relevant articles and documents

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

Site-Selectivity in the Cyanation of 3-Substituted Pyridine 1-Oxides with Trimethylsilanecarbonitrile

The cyanation of 3-halo-, 3-methoxy-, and 3-dimethylaminopyridine 1-oxide with trimethylsilanecarbonitrile gave predominantly the corresponding 3-substituted 2-pyridinecarbonitriles.The deoxygenation of nitropyridine 1-oxides to nitropyridines with the same reagent is also described.Keywords - site-selective reaction; trimethylsilanecarbonitrile; pyridine 1-oxide; 2-pyridine-carbonitrile; nitropyridine 1-oxide; deoxygenation; aromatic amine N-oxide; cyanation