76218-89-8

Basic information

• Product Name: Benzamide, N,N-1,4-butanediylbis(2-hydroxy-
• CAS NO: 76218-89-8
• Molecular Formula: C₁₈H₂₀N₂O₄
• Molecular Weight: 328.368
• Mol File: 76218-89-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 634.3°Cat760mmHg
• Flash Point: 337.4°C
• Density: 1.258g/cm³
• CAS DataBase Reference: Benzamide, N,N-1,4-butanediylbis(2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N,N-1,4-butanediylbis(2-hydroxy-(76218-89-8)
• EPA Substance Registry System: Benzamide, N,N-1,4-butanediylbis(2-hydroxy-(76218-89-8)

Safety Data

• Hazardous Substances Data: 76218-89-8(Hazardous Substances Data)

Upstream product

• 14389-86-7 2-benzyloxybenzoic acid 
• 110-60-1 1,4-diaminobutane 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 
• 118-55-8 phenyl Salicylate 

Downstream Products

• 1187784-79-7 C₃₀H₂₈N₂O₄ 

Relevant articles and documents

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors

Linear and branched compounds that contain two, three or five units of galloyl (3,4,5-trihydroxybenzoyl) or its isomer 2,3,4-trihydroxybenzoyl, as well as other mono- or dihydroxybenzoyl moieties have been synthesized. These molecules have been evaluated for their in vitro inhibitory effects against a wide panel of viruses showing preferential activity against HIV and HCV. Our structure-activity relationship studies demonstrated that the 2,3,4-trihydroxybenzoyl moiety provides better antiviral activities than the galloyl (3,4,5-trihydroxybenzoyl) moiety that is present in natural green tea catechins. This observation can be of interest for the further rational exploration of compounds with anti-HCV/HIV properties. The most notable finding with respect to HIV is that the tripodal compounds 43 and 45, with three 2,3,4-trihydroxybenzoyl moieties, showed higher activities than linear compounds with only one or two. With respect to HCV, the linear compounds, 52 and 41, containing a 12 polymethylene chain and two 2,3 di- or 2,3,4 tri-hydroxybenzoyl groups respectively at the ends of the molecule showed good antiviral efficiency. Furthermore, the anti-HCV activity of both compounds was observed at concentrations well below the cytotoxicity threshold. A representative member of these compounds, 41, showed that the anti-HCV activity was largely independent of the genetic make-up of the HCV subgenomic replicon and cell lines used.

A Convenient Method for Preparing Some New Macrocyclic Diamides

A simple and convenient method for preparing macrocyclic diamides containing two sulfur atoms or two to four oxygen atoms of various ring sizes was developed.This two-step procedure is simply composed of reacting salicylic acid or 2-mercaptobenzoic acid w

Synthesis and evaluation of the analgesic and antiinflammatory activities of N,N'-bis (2-hydroxybenzoyl)- diaminoalkanes

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