76283-12-0 Usage
Description
1-(bromomethyl)-4-chloro-2-methoxybenzene, with the molecular formula C8H8BrClO, is an aromatic chemical compound featuring a benzene ring to which a bromomethyl group, a chloro group, and a methoxy group are attached. This versatile compound serves as a crucial intermediate in the synthesis of various organic molecules, particularly in the pharmaceutical and agrochemical industries.
Uses
Used in Pharmaceutical Industry:
1-(bromomethyl)-4-chloro-2-methoxybenzene is used as a synthetic intermediate for the development of new pharmaceuticals. Its unique structure, including the bromomethyl, chloro, and methoxy groups, allows for the creation of a diverse range of medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(bromomethyl)-4-chloro-2-methoxybenzene is utilized as a building block for the synthesis of various agrochemicals, such as pesticides and herbicides. Its chemical properties make it suitable for the development of effective compounds to protect crops and enhance agricultural productivity.
Used in Dye Production:
1-(bromomethyl)-4-chloro-2-methoxybenzene is also employed in the production of dyes due to its aromatic structure and functional groups. Its versatility allows for the synthesis of a wide array of dye molecules with different color properties and applications in various industries, such as textiles and printing.
Used in Polymer Synthesis:
1-(bromomethyl)-4-chloro-2-methoxybenzene is used as a monomer or a building block in the synthesis of polymers. The presence of the bromomethyl, chloro, and methoxy groups in 1-(bromomethyl)-4-chloro-2-methoxybenzene enables the creation of polymers with specific properties, such as enhanced stability, reactivity, or solubility, which can be tailored for various applications.
Used in Organic Chemistry:
1-(bromomethyl)-4-chloro-2-methoxybenzene is a valuable compound in organic chemistry, serving as a starting material for the synthesis of various organic molecules. Its unique structure allows for further functionalization and modification, leading to the development of new compounds with a broad spectrum of applications in research and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 76283-12-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,2,8 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 76283-12:
(7*7)+(6*6)+(5*2)+(4*8)+(3*3)+(2*1)+(1*2)=140
140 % 10 = 0
So 76283-12-0 is a valid CAS Registry Number.
76283-12-0Relevant articles and documents
RORγ MODULATORS
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Page/Page column 21; 38-39; 68, (2018/04/13)
The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.
Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents
Marchand, Pascal,Antoine, Maud,Baut, Guillaume Le,Czech, Michael,Baasner, Silke,Guenther, Eckhard
experimental part, p. 6715 - 6727 (2009/12/06)
The synthesis and study of the structure-activity relationships of cytotoxic compounds based on N-pyridinyl or N-aryl-2-(1-benzylindol-3-yl)glyoxamide skeleton, represented by the lead structures D-24241 and D-24851, are described. The presence of N-(pyridin-4-yl) moiety was crucial for activity and 2-[1-(4-chloro-3-nitrobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)aceta mide (55), the most potent derivative, showed IC50 = 39 nM, 51 nM and 11 nM against HeLa/KB (human cervix carcinoma), L1210 (murine leukemia) and SKOV3 (human ovarian carcinoma) cell lines proliferation assay, respectively, as active as the lead compounds.
Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines
Kelley,Linn,Selway
, p. 1757 - 1763 (2007/10/02)
A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.
