76350-03-3

Basic information

• Product Name: 5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride
• Synonyms: 5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride
• CAS NO: 76350-03-3
• Molecular Formula: C₁₁H₆Cl₂I₃NO₄
• Molecular Weight: 667.78905
• Mol File: 76350-03-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 628.2±55.0 °C(Predicted)
• Appearance: /
• Density: 2.525±0.06 g/cm3(Predicted)
• PKA: 10.32±0.70(Predicted)
• CAS DataBase Reference: 5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride(76350-03-3)
• EPA Substance Registry System: 5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride(76350-03-3)

Safety Data

• Hazardous Substances Data: 76350-03-3(Hazardous Substances Data)

Usage

General Description

5-Methoxyacetamido-2,4,6-triiodoisophthaloyl chloride is a chemical compound that is used in the medical field as a contrast agent for enhancing the visibility of internal structures during imaging procedures such as CT scans. It contains three iodine atoms, which allows it to absorb X-rays and appear opaque on imaging, making it useful for highlighting specific areas of the body. The compound is typically used to improve the clarity and accuracy of diagnostic imaging, particularly in the visualization of blood vessels, organs, and other soft tissues. Its unique structure and properties make it valuable in the field of medical imaging for aiding in the detection and diagnosis of various health conditions.

Upstream product

• 625-45-6 2-methoxyacetic acid 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 
• 38870-89-2 Methoxyacetyl chloride 

Downstream Products

• 73334-07-3 iopromide 
• 76350-04-4 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride 

Relevant articles and documents

Method for preparing iopromide intermediate

The invention discloses a method for preparing an iopromide intermediate. The method comprises the following steps: 1) taking a compound I5-amino-2,4,6-triiodo-1,3-benzoyl chloride and methoxyacetyl chloride as raw materials, triethylamine as an acidifyin

A method for preparing [...]

The present invention relates to an X-ray contrast agent iopromide preparation method. According to the method, 3-methoxy acetyl-5-(2,3-dihydroxy-N-methyl-n-propyl-carbamoyl)-2,4,6-triiodobenzoic acid (4) is introduced as an intermediate, the used raw material is cheap and easy to obtain, the experiment operation is relatively simple, the reaction condition is mild, and the product purity is qualified.

A new method for synthesizing iodine proletariat amine

The invention discloses a novel synthesis method for iopromide. The novel synthesis method comprises the following steps of 1, enabling methoxyacetic acid to react with triphosgene to obtain a reaction product, and then, enabling the reaction production to be directly subjected to one-pot reaction with 5-amino-2, 4, 6-triiodo-isophthalicacyl chloride to prepare a compound 5-[(2-methoxyl) acetamido]-2, 4, 6-triiodo-isophthalicacyl chloride as shown in the formula (II); 2, condensing the compound as shown in the formula (II) and N-methyl-2, 3-dihydroxyl propylamine under the action of a solid catalyst ZrO2-Cr2O3 to obtain a compound 5-[(2-methoxyl) acetamido]-3-(2, 3-dihydroxyl-N-methylpropylaminoformoxyl)-2, 4, 6-triiodo-benzoyl chloride as shown in the formula (III); 3, condensing the compound as shown in the formula (III) and 2, 3-dihydroxylpropylamine under the action of a catalyst to prepare a compound iopromide as shown in the formula (I). The synthesis method for iopromide, disclosed by the invention, is few in byproduct, easy to control the product quality, high in product purity, cheap and easily-obtained in used reagent, few in step, simple in operation, relatively high in total yield and suitable for industrial production, and provides a novel approach for preparing iopromide.