76362-28-2

Basic information

• Product Name: N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE
• Synonyms: N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE;3-[(4-AMino-6,7-diMethoxy-2-quinazolinyl)MethylaMino]propanenitrile
• CAS NO: 76362-28-2
• Molecular Formula: C14H17N5O2
• Molecular Weight: 287.31708
• Product Categories: Aromatics;Isotope Labeled Compounds;Amines;Isotope Labelled Compounds
• Mol File: 76362-28-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 535.4 °C at 760 mmHg
• Flash Point: 277.6 °C
• Appearance: /
• Density: 1.278 g/cm³
• Vapor Pressure: 1.54E-11mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE(76362-28-2)
• EPA Substance Registry System: N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE(76362-28-2)

Safety Data

• Hazardous Substances Data: 76362-28-2(Hazardous Substances Data)

Usage

Description

N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE is a chemical compound with the molecular structure characterized by a quinazoline core, featuring an amino group at the 4-position and methoxy groups at the 6 and 7 positions. It also has a cyanoethylamine side chain attached to the nitrogen atom. N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE is a white solid and is known for its potential applications in the pharmaceutical industry, particularly as an intermediate in the synthesis of Alfuzosin, a drug that acts as an α1-adrenoceptor antagonist.

Uses

Used in Pharmaceutical Industry:
N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE is used as an intermediate in the synthesis of Alfuzosin, a medication that serves as a potential α1-adrenoceptor antagonist. Its role in the synthesis process is crucial for the development of this drug, which is used to treat various conditions related to prostate enlargement and other related urinary issues.
Used in Chemical Research:
As a chemical compound with unique structural features, N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE can also be utilized in chemical research for the exploration of new drug candidates, understanding its reactivity, and investigating its potential interactions with various biological targets. This can lead to the discovery of new therapeutic agents and a better understanding of its pharmacological properties.

InChI:InChI=1/C14H17N5O2/c1-19(6-4-5-15)14-17-10-8-12(21-3)11(20-2)7-9(10)13(16)18-14/h7-8H,4,6H2,1-3H3,(H2,16,17,18)

Upstream product

• 693-05-0 N-(2-cyanoethyl)-N-methylamine 
• 23680-84-4 2-chloro-6,7-dimethoxyquinazolin-4-amine 
• 132900-51-7 4-amino-2-chloro-6,7-dimethoxyquinazoline hydrochloride 

Downstream Products

• 76362-29-3 N¹-methyl-N¹-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine 

Relevant articles and documents

PROCESS FOR PREPARING ALFUZOSIN

Processes for preparing alfuzosin and pharmaceutically acceptable salts, solvates, hydrates thereof are disclosed. The present invention also discloses processes for preparation of anhydrous alfuzosin hydrochloride having substantially free from other pseudopolymorphic crystalline forms particularly dihydrate form of alfuzosin hydrochloride.

PROCESS FOR THE PREPARATION OF ALFUZOSIN

The present invention relates to a simple process for the preparation of alfuzosin, it's bases and its pharmaceutically acceptable salts thereof.

PROCESSES FOR THE PREPARATION OF ALFUZOSIN

The invention relates to processes for the preparation of alfuzosin or pharmaceutically acceptable salts thereof in high purity. More particularly, it relates to the preparation of pure crystalline alfuzosin base. The invention also relates to pharmaceutical compositions that include the pure alfuzosin or a pharmaceutically acceptable salt thereof.