76371-66-9

Basic information

• Product Name: 3-BROMOTHIOPHENE-2-CARBOXAMIDE
• Synonyms: BUTTPARK 144\02-04;3-BROMOTHIOPHENE-2-CARBOXAMIDE;3-Bromothiophene-2-carboxamide ,99%;5-bromothiophene-2-carboxamide;2-thiophenecarboxamide, 5-bromo-;Albb-010193;5-Bromothiophene-2-carboxamide ,95%;5-bromo-2-thiophenecarboxamide(SALTDATA: FREE)
• CAS NO: 76371-66-9
• Molecular Formula: C₅H₄BrNOS
• Molecular Weight: 206.06
• EINECS: -0
• Mol File: 76371-66-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 77-78°C
• Boiling Point: 318 °C at 760 mmHg
• Flash Point: 146.1 °C
• Appearance: /
• Density: 1.81 g/cm³
• Vapor Pressure: 0.0009mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.55±0.50(Predicted)
• BRN: 4937660
• CAS DataBase Reference: 3-BROMOTHIOPHENE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMOTHIOPHENE-2-CARBOXAMIDE(76371-66-9)
• EPA Substance Registry System: 3-BROMOTHIOPHENE-2-CARBOXAMIDE(76371-66-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-20/21/22
• Safety Statements: 3/7-24/25-36/37-15
• HazardClass: IRRITANT
• Hazardous Substances Data: 76371-66-9(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

InChI:InChI=1/C5H4BrNOS/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H2,7,8)

Upstream product

• 2160-62-5 5-bromo-2-thiophenecarbonitrile 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 2160-63-6 5-bromo-thiophene-2-carbaldehyde oxime 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 5370-25-2 2-Acetyl-5-bromothiophene 
• 31555-60-9 5-bromothiophene-2-carbonyl chloride 

Relevant articles and documents

Highly efficient synthesis of primary amides: Via aldoximes rearrangement in water under air atmosphere catalyzed by an ionic ruthenium pincer complex

The transformation of aldoximes to primary amides has been evaluated using pincer ruthenium complexes a-c, among which the ionic Ru catalyst a proved to be the most efficient in water under air atmosphere. A variety of (hetero)arene aldoximes proceeded smoothly to afford amides in high yields with good functional group compatibilities. Furthermore, a direct synthetic route of amides from aldehydes, hydroxylamine hydrochloride and sodium carbonate was also described with broad substrates including conjugated and aliphatic aldehydes. This protocol is operationally simple and proceeds with a low catalyst loading (0.5 mol%).

Et4NI-catalyzed amidation of aldehydes and alcohols with ammonium salts

An efficient method for the oxidative amidation of benzylic aldehydes or alcohols with ammonium salts has been developed for the synthesis of primary amides using Et4NI as the catalyst and tert-butyl hydroperoxide as the oxidant. This amidation reaction is operationally straightforward and provides primary amides in moderate to good yields under mild conditions.

IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.