76457-90-4

Basic information

• Product Name: 4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole
• Synonyms: 4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole
• CAS NO: 76457-90-4
• Molecular Weight: 235.313
• Mol File: 76457-90-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole(76457-90-4)
• EPA Substance Registry System: 4-amino-5-[4-(N,N-dimethylamino)phenyl]-3-mercapto-1,2,4-triazole(76457-90-4)

Safety Data

• Hazardous Substances Data: 76457-90-4(Hazardous Substances Data)

Upstream product

• 1251851-80-5 C₁₀H₁₂N₃O₂S^(1-)*K⁽¹⁺⁾ 
• 19353-92-5 4-(dimethylamino)benzohydrazide 
• 75-15-0 carbon disulfide 
• 94074-13-2 Potassium 3-(p-Dimethylaminobenzoyl)dithiocarbazinate 

Downstream Products

• 1251851-84-9 4-((aminomethylene)-2'-(4''-chlorophenyl)-5'-methoxy indol-3'yl)-3-(4-N,N-dimethyl aminophenyl)-5-mercapto-1,2,4-triazole 
• 1251851-88-3 4-((aminomethylene)-2'-(4''-bromophenyl)-5'-methoxyindol-3'yl)-3-(4-N,N-dimethylaminophenyl)-5-mercapto-1,2,4-triazole 
• 1161408-50-9 3-(4-(N,N-dimethylamino)phenyl)-6-(1-phenyl-pyrrol-2-yl)-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-28-1 3-(4-(N,N-dimethylamino)phenyl)-6-[(5-methoxy-2-methyl-1H-indol-3-yl)methyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-25-8 3-(4-(N,N-dimethylamino)phenyl)-6-[(5-methoxy-1H-indol-3-yl)methyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-22-5 3-(4-(N,N-dimethylamino)phenyl)-6-[(1H-indol-3-yl)methyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-35-0 3-(4-(N,N-dimethylamino)phenyl)-6-[5-nitro-2-furanyl]-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-14-5 3-(4-(N,N-dimethylamino)phenyl)-6-(2-fluoro-pyridin-4-yl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-17-8 3-(4-(N,N-dimethylamino)phenyl)-6-(2-methyl-pyridin-4-yl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 878431-53-9 3-(4-(N,N-dimethylamino)phenyl)-6-(pyridin-4-yl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-39-4 3-(4-(N,N-dimethylamino)phenyl)-6-[5-chloro-2-furanyl]-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-47-4 3-(4-(N,N-dimethylamino)phenyl)-6-(1-methyl-pyrrol-2-yl)-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-32-7 3-(4-(N,N-dimethylamino)phenyl)-6-[2-furanyl]-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 
• 1161408-42-9 3-(4-(N,N-dimethylamino)phenyl)-6-(1H-pyrrol-2-yl)-5,6-dihydro-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole 

Relevant articles and documents

Synthesis and biological evaluation of novel glycosyl-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives as acetylcholinesterase inhibitors

An efficient protocol for the synthesis of novel glycosyl-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives starting from the commercially available d-glucosamine hydrochloride is described by reaction of glycosyl isothiocyanate with various aminotriazoles in DMF. Glycosyl isothiocyanate is an important intermediate and synthetic methods are discussed. The acetylcholinesterase inhibitory activity of these compounds was tested by Ellman’s method. It was found that most compounds exhibited over 90% inhibition and they were subsequently evaluated for their IC50values.

Studies on synthesis and pharmacological activities of 1,2,4- triazolo[3,4-b]1,3,4-thiadiazoles and their dihydro analogues

4-Amino-5-substituted aryl-3-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Starting from 4-amino-5-substituted aryl-3-mercapto-1,2,4- triazole 3a-c, a series of new 3,5-disubstituted-1,2,4-triazolo-[3,4-b]1,3,4-thiadiazoles and their 5,6-dihydrotriazolothiadiazoles were prepared. The structures of all the newly synthesized compounds have been confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR, and mass spectra. The antimicrobial effects of the synthesized compounds were investigated using the paper disc method. Anti-inflammatory and analgesic activities of the synthesized compounds were assessed by carrageenan-induced rat paw oedema method and by Eddy's hot plate method, respectively. Some of the compounds exhibited promising antimicrobial activities as well as moderate to good anti-inflammatory activity and analgesic activity.

4-Amino-3-mercapto-4H-1,2,4-triazoles and propargyl aldehydes: A new route to 3-R-8-aryl-1,2,4-triazolo[3,4-b]1,3,4-thiadiazepines

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