764634-04-0Relevant articles and documents
N-cyclohexylethyl-N-noroxymorphindole: A μ-opioid preferring analogue of naltrindole
Coop, Andrew,Jacobson, Arthur E.,Aceto, Mario D.,Harris, Louis S.,Traynor, John R.,Woods, James H.,Rice, Kenner C.
, p. 2449 - 2451 (2000)
The position of the indole in the indolomorphinans, which includes the δ opioid antagonist naltrindole, is considered to be responsible for the δ opioid selectivity for this class of ligands. Herein is described the N-cyclohexylethyl substituted N-nor-derivative, which is shown to be μ preferring. Thus, the nature of the N-substituent is equally important to the receptor selectivity for this class of ligands. (C) 2000 Elsevier Science Ltd.