7647-10-1

Basic information

• Product Name: Palladium chloride
• Synonyms: PALLADIUM(+2)CHLORIDE;PALLADIUM DICHLORIDE;PALLADIUM CHLORIDE(II);PALLADIUM CHLORIDE;PALLADIUM(II) CHLORIDE;enplateactivator440;nci-c60184;palladiumchloride(pdcl2)
• CAS NO: 7647-10-1
• Molecular Formula: Cl₂Pd
• Molecular Weight: 177.33
• EINECS: 231-596-2
• Product Categories: blocks;Inorganics;Catalysts for Organic Synthesis;Classes of Metal Compounds;Homogeneous Catalysts;Pd (Palladium) Compounds;Synthetic Organic Chemistry;Titanium Alkoxides, etc. (Homogeneous Catalysts);Transition Metal Compounds;Homogeneous Pd CatalystsMetal and Ceramic Science;Palladium Salts;Salts;Catalysis and Inorganic Chemistry;Homogeneous Pd Catalysts;Palladium;Crystal Grade Inorganics;PalladiumMetal and Ceramic Science;metal halide;chemical reaction,pharm,electronic,materials;Pd
• Mol File: 7647-10-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 678-680 °C(lit.)
• Boiling Point: 100oC
• Appearance: Yellow/Powder/Solid
• Density: 4 g/mL at 25 °C(lit.)
• Vapor Pressure: 24.5mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Solubility: 55.6g/l insoluble
• Water Solubility: Insoluble
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,6990
• CAS DataBase Reference: Palladium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Palladium chloride(7647-10-1)
• EPA Substance Registry System: Palladium chloride(7647-10-1)

Safety Data

• Hazard Codes: C,Xi,T+,T,Xn
• Statements: 34-43-40-28-41-37/38-25-22
• Safety Statements: 26-36/37/39-45-37/39-28-27-36/37-27/28
• RIDADR: UN 1789 8/PG 3
• WGK Germany: 2
• RTECS: RT3500000
• F: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 7647-10-1(Hazardous Substances Data)

Usage

Chemical Description

Palladium chloride and lithium chloride are used in the preparation of [PdCl{1-(1-naphthyl)-1-methyl-p-allyl}].

Chemical Description

Palladium chloride is a compound with the formula PdCl2.

InChI:InChI=1/2ClH.2H2O.Pd/h2*1H;2*1H2;/q;;;;+2/p-2

Synthetic route

N,N,N,N,-tetramethylethylenediamine (110-18-9) + palladium(II) chloride (7647-10-1) → N,N,N',N'-tetramethylethylenediamine palladium(II) chloride (14267-08-4)

Conditions	Yield
In acetonitrile refluxing PdCl2-acetonitrile solution; cooling to 20°C; adding tmeda; analysis;	90%

N,N,N'N'-tetramethyl-1,3-propanediamine (110-95-2) + palladium(II) chloride (7647-10-1) → dichlor(N,N,N',N'-tetramethyl-1,3-propanediamine)palladium(II) (21363-94-0)

Conditions	Yield
In acetonitrile refluxing PdCl2-acetonitrile solution; cooling to 20°C; adding tmpda; analysis;	90%

4-but-2-enyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester + palladium(II) chloride (7647-10-1) → 4-(3-oxo-butyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Conditions	Yield
copper(I) chloride In water; N,N-dimethyl-formamide	71%

copper(II) chloride dihydrate + 4-allylazetidin-2-one (68485-52-9) + palladium(II) chloride (7647-10-1) + sodium hydrogencarbonate (144-55-8) → 4-(2-oxo-propyl)-azetidin-2-one (68485-90-5)

Conditions	Yield
mercury(II) diacetate In methanol; ethyl acetate	70%
mercury(II) diacetate In methanol; ethyl acetate	70%

4-bromo-1,3-benzenedicarboxylic acid dimethyl ester (28730-78-1) + para-fluorostyrene (405-99-2) + palladium(II) chloride (7647-10-1) → methyl 4-[2-4-fluorophenyl)ethenyl]-3-methoxycarbonylbenzoate + (2S)-2-{2-(4-fluorophenethyl)-5-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethylaminomethyl]benzoylamino}-4-methylsulfanylbutyric acid

Conditions	Yield
With tributyl-amine In dichloromethane; water

4-bromo-1,3-benzenedicarboxylic acid dimethyl ester (28730-78-1) + para-fluorostyrene (405-99-2) + palladium(II) chloride (7647-10-1) → methyl 4-[2-(4-fluorophenyl)ethenyl]-3-methoxycarbonylbenzoate

Conditions	Yield
With tributyl-amine In dichloromethane; water

1-bromo-4-methoxy-benzene (104-92-7) + palladium(II) chloride (7647-10-1) + potassium carbonate (584-08-7) + acrylic acid (79-10-7) → 3-(4'-methoxyphenyl)propenoic acid (830-09-1)

Conditions	Yield
In water

6-fluoro-3-nitroaniline (369-36-8) + palladium(II) chloride (7647-10-1) + 2,4-Dinitrofluorobenzene (70-34-8) → 4-Fluoro-3-nitroaniline (364-76-1)

Conditions	Yield
In palladium dichloride

cupric chloride + C2 H5 O(C2 H4 O)18 C2 H5 + 1,11-dodecadiene (5876-87-9) + palladium(II) chloride (7647-10-1) → 1-dodecen-11-one (5009-33-6) + 2,11-dodecadione (7029-09-6)

Conditions	Yield
In water

cupric chloride + C2 H5 O(C2 H4 O)18 CH3 + 6-methyl-1,5-heptadiene (7270-50-0) + palladium(II) chloride (7647-10-1) → 6-Methyl-hept-5-en-2-on (110-93-0)

Conditions	Yield
In water

furfural (98-01-1) + palladium(II) chloride (7647-10-1) + N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine (231278-20-9) → 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate

Conditions	Yield
With N2; potassium acetate In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide	2.5 g (55%)

1,1'-bis(diphenylphosphino) ferrocene + palladium(II) chloride (7647-10-1) + 2-(4-{2-[2-(4-bromophenyl)-5-methyloxazol-4-yl]ethoxy}phenoxy)-2-methylpropionic acid ethyl ester (328918-90-7) + phenylboronic acid (98-80-6) → 2-[4-(2-{2-[4-(4-Benzoyl-phenoxy)-phenyl]-5-methyl-oxazol-4-yl}-ethoxy)-phenoxy]-2-methyl-propionic Acid

Conditions	Yield
With sodium hydroxide; K2CO3; potassium iodide In ethanol; methoxybenzene

1-Heptene (592-76-7) + palladium(II) chloride (7647-10-1) → 2C5H11CHCH2*2PdCl2={C5H11CHCH2PdCl2}2

Conditions	Yield
In tetrahydrofuran Pd-compd. and 1-heptene (1.4 molar ratio) in THF stirred at room temp. for 30 min.;

Downstream Products

• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 364-76-1 4-Fluoro-3-nitroaniline 
• 68485-90-5 4-(2-oxo-propyl)-azetidin-2-one 
• 5009-33-6 1-dodecen-11-one 
• 7029-09-6 2,11-dodecadione 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 14267-08-4 N,N,N',N'-tetramethylethylenediamine palladium(II) chloride 
• 388082-75-5 5-(4-[3-chloro-4-(3-fluorobenzyloxy)-anilino]-6-quinazolinyl)-furan-2-carbaldehyde 4-methylbenzenesulfonate 

Relevant articles and documents

Method for preparing of L-phenylephrine hydrochloride

The present invention relates to an improved process for preparing L-phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the key step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as the catalyst system.