765-01-5Relevant articles and documents
Preparation method of royal jelly acid
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Paragraph 0026; 0029; 0031; 0033; 0034; 0036-0037; 0039-0040, (2019/07/01)
The invention discloses a preparation method of royal jelly acid, and belongs to the field of chemical synthesis. The preparation method comprises the following steps: taking 1, 10-decanediol as a rawmaterial, taking water as a solvent, and under the action of potassium persulfate and tetraalkyl ammonium bromide, preparing a 2-bromodecalactone (II) compound, wherein the reaction adopts an one-potmethod to carry out three step reactions of oxidation, lactonization and alpha-H bromination respectively, and has relatively high selectivity and yield; and carrying out hydrolysis and elimination reaction on the 2-bromodecalactone (II) compound, and finally carrying out acidifying to obtain a royal jelly acid target product; the purity of a crude product can reach 95%, and the purity of the product reaches more than 99% after recrystallization. According to the method, the royal jelly acid is prepared by adopting two steps, and the preparation method has the advantages of short route and simplicity and convenience in operation, is easy for industrial production, and is a method for synthesizing the royal jelly acid very economically and simply.
Novel Method for Preparing Unsaturated Fatty Hydroxyacids
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Page/Page column 11, (2008/12/08)
The invention concerns a method for preparing a compound of formula (I), wherein: R3 and R1 represent in particular H and n is greater than 4, said preparation method including performing a Wittig-Horner reaction with a phosphonate on a lactol, so as to obtain a hydroxyester and, optionally a saponification reaction of said hydroxyester.