765252-40-2

Basic information

• Product Name: C₁₁H₁₆N₂O₄S
• CAS NO: 765252-40-2
• Molecular Weight: 272.325
• Mol File: 765252-40-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₆N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₆N₂O₄S(765252-40-2)
• EPA Substance Registry System: C₁₁H₁₆N₂O₄S(765252-40-2)

Safety Data

• Hazardous Substances Data: 765252-40-2(Hazardous Substances Data)

Upstream product

• 85952-29-0 (4-nitro-phenyl)-methanesulfonic acid methylamide 
• 197580-86-2 N-ethoxycarbonyl-N-methyl-4-nitrobenzenemethanesulphonamide 

Relevant articles and documents

Synthesis of 5-substituted indole derivatives, I. An improved method for the synthesis of sumatriptan

An improved synthesis of sumatriptan (1b) via Fischer cyclization was achieved by introducing the ethoxycarbonyl group on the N-atom of the sulphonamide moiety in N-methyl-4-hydrazinobenzenemethanesulphonamide (7). As a result, substitution on the benzylic carbon of the indole nucleus could be avoided; however, formation of 1,1-bis-(indol-2-yl)-4-dimethylaminobutane-type by-product (19) was observed. The indolization procedure was optimized to suppress the unwanted side reaction. The N-protection of the sulphonamide moiety was found to be beneficial regarding the purification of the 3-[2-(dimethylamino)ethyl]-N-ethoxycarbonyl-N-methyl-1H-indole-5- methanesulphonamide (18).