76530-89-7

Basic information

• Product Name: Bis(3,4-methylenedioxy)chalcone
• Synonyms: 1,3-Bis(1,3-benzodioxol-5-yl)-2-propen-1-one;3,4:3',4'-bis(methylenedioxy)chalcone;Bis(3,4-methylenedioxy)chalcone;NSC 162494;1,3-Bis(1,3-benzodioxol-5-yl)-
• CAS NO: 76530-89-7
• Molecular Formula: C17H12O5
• Molecular Weight: 296.27418
• Product Categories: Aromatics;Heterocycles
• Mol File: 76530-89-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 490.1°C at 760 mmHg
• Flash Point: 220.3°C
• Appearance: /
• Density: 1.396g/cm³
• Vapor Pressure: 9.42E-10mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: Bis(3,4-methylenedioxy)chalcone(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(3,4-methylenedioxy)chalcone(76530-89-7)
• EPA Substance Registry System: Bis(3,4-methylenedioxy)chalcone(76530-89-7)

Safety Data

• Hazardous Substances Data: 76530-89-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 76530-89-7 differently. You can refer to the following data:
1. Used for the treatment of amyloid diseases and synucleinopathies such as Alzheimer disease, type 2 diabetes, and Parkinson disease.
2. Bis(3,4-methylenedioxy)chalcone is used for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease.

InChI:InChI=1/C17H12O5/c18-13(12-3-6-15-17(8-12)22-10-20-15)4-1-11-2-5-14-16(7-11)21-9-19-14/h1-8H,9-10H2/b4-1+

Upstream product

• 120-57-0 piperonal 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 

Relevant articles and documents

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols provides chalcones and benzyl styrenes. The use of various metal triflates is investigated herein for facile and efficient redox transformation. A plausible mechanism has been proposed.

A simple and scalable procedure for TiCl4-promoted aldol reaction

TiCl4-promoted aldol reaction was carried out by adding TiCl4 to a solution of the aldol reaction substrates and (i-Pr) 2NEt (DIPEA) in CH2Cl2. Compared to the conventional order of addition (sequentially adding TiCl4, DIPEA, and piperonal to the lactone 2 in CH2Cl2), this simplified procedure, gave a much cleaner reaction that could be executed on large scale and without cryogenic cooling. However this procedure provided no stereoselectivity.