76584-70-8 Usage
Description
Divalproex sodium is a prodrug form of valproic acid that contains valproic acid and valproate sodium. It is formulated to exhibit delayed gastrointestinal absorption and is converted to valproic acid in the intestine, reducing gastric irritation and nervous system side effects. Divalproex sodium is widely used for the treatment of seizures and bipolar disorder.
Uses
Used in Pharmaceutical Industry:
Divalproex sodium is used as an antiepileptic and anticonvulsant agent for the treatment of seizures. It is also used as a mood stabilizer for individuals with bipolar disorder.
Used in Mental Health Treatment:
In rare cases, Divalproex sodium is used as a treatment for major depressive disorder, and is increasingly taken long-term for prevention of mood episodes in bipolar disorder.
Used in Neurology:
Divalproex sodium is used as an anticonvulsant and bipolar agent for the management of seizure disorders and mood disorders.
Originator
Depakote,Abbott
Manufacturing Process
Dipropyl acetic acid or valproic acid may be prepared the next way.
Propylbromide is mixed with cyanacetic acid in the presence of sodium
ethylate, made from absolute ethanol and sodium. By that prepared α,α-
dipropylcyanacetic acid ethyl ester is saponified with equimolecular amounts
of NaOH to give dipropylacetonitril. The desired dipropylacetic acid is produced
by saponification of dipropylacetonitryl with aquatic NaOH. It is colorless
liquid. BP 219°-220°C.Sodium salt of this acid may be prepared by adding of equivalent of NaOH.
Therapeutic Function
Anticonvulsant
Clinical Use
Treatment of manic episodes associated with bipolar disorder Migraine prophylaxis (unlicensed)
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly inhibited
by erythromycin; avoid with pivmecillinam;
concentration reduced by carbapenems - avoid.
Antidepressants: avoid with St John’s wort.
Antiepileptics: concentration reduced by
carbamazepine; concentration of active
carbamazepine metabolite increased; increased
concentration of lamotrigine, phenobarbital,
rufinamide and possibly ethosuximide; sometimes
reduces concentration of active metabolite of
oxcarbazepine; alters phenytoin concentration;
phenytoin and phenobarbital reduce valproate
concentration; hyperammonaemia and CNS toxicity
with topiramate.
Antipsychotics: increased neutropenia with
olanzapine; possibly increases or decreases
concentration of clozapine; possibly increases
quetiapine concentration.
Ciclosporin: variable ciclosporin blood level response.
Sodium oxybate: concentration of sodium oxybate
increased.
Ulcer-healing drugs: metabolism inhibited by
cimetidine, increased concentration.
Metabolism
Valproic acid is extensively metabolised in the liver, a large
part by glucuronidation (up to 60%) and the rest by a
variety of complex pathways (up to 45%). It is excreted in
the urine almost entirely in the form of its metabolites;
small amounts are excreted in faeces and expired air.
Check Digit Verification of cas no
The CAS Registry Mumber 76584-70-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,5,8 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 76584-70:
(7*7)+(6*6)+(5*5)+(4*8)+(3*4)+(2*7)+(1*0)=168
168 % 10 = 8
So 76584-70-8 is a valid CAS Registry Number.
InChI:InChI=1/2C8H16O2.Na/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+1/p-1
