7662-51-3

Basic information

• Product Name: L-TYROSINE HYDRAZIDE
• Synonyms: L-TYROSINE HYDRAZIDE;H-TYR-NHNH2;L-tyrosinohydrazide;Tyrosinehydrazide;L-TYROSINE HYDRAZIDE 98%;L-Tyrosine hydrazide,98%;(S)-2-AMino-3-(4-hydroxyphenyl)propanehydrazide;L-Tyrosine Hydrazide
• CAS NO: 7662-51-3
• Molecular Formula: C₉H₁₃N₃O₂
• Molecular Weight: 195.22
• EINECS: 231-631-1
• Product Categories: Amino Acid Derivatives;Peptide Synthesis;Tyrosine
• Mol File: 7662-51-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 196-198 °C(lit.)
• Boiling Point: 331.89°C (rough estimate)
• Flash Point: 250.6 °C
• Appearance: white fine crystals
• Density: 1.1985 (rough estimate)
• Vapor Pressure: 2.94E-10mmHg at 25°C
• Refractive Index: 78 ° (C=5, 1mol/L HCl)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: almost transparency in 1mol/L HCl
• BRN: 2808635
• CAS DataBase Reference: L-TYROSINE HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-TYROSINE HYDRAZIDE(7662-51-3)
• EPA Substance Registry System: L-TYROSINE HYDRAZIDE(7662-51-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 7662-51-3(Hazardous Substances Data)

Usage

Description

L-TYROSINE HYDRAZIDE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and chemicals. It is a white crystalline solid and is known for its ability to resolve DL-amino acids, making it a valuable compound in the field of chemistry and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
L-TYROSINE HYDRAZIDE is used as a resolving agent for various DL-amino acids, playing a significant role in the separation and purification of these essential building blocks of proteins. This application is crucial in the development and production of various pharmaceuticals, as amino acids are the primary constituents of many drugs.
Used in Chemical Research:
L-TYROSINE HYDRAZIDE is used as an excellent reagent for the resolution of amino acids in chemical research. Its ability to resolve DL-amino acids makes it a valuable tool for scientists and researchers working on the development of new drugs and the study of protein structures. This application aids in advancing our understanding of the molecular basis of various diseases and the design of targeted therapeutics.

InChI:InChI=1/C9H13N3O2/c10-8(9(14)12-11)5-6-1-3-7(13)4-2-6/h1-4,8,13H,5,10-11H2,(H,12,14)/p+1/t8-/m0/s1

Upstream product

• 3417-91-2 L-tyrosine methyl ester HCl 
• 60-18-4 L-tyrosine 
• 949-67-7 L-tyrosine ethyl ester 
• 1080-06-4 L-Tyr-OMe 

Downstream Products

• 101590-02-7 Tyr-NH-NH-CH(CH₃)2 
• 1337535-19-9 5-(4-hydroxybenzyl)-3-phenyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one 
• 1448820-03-8 5-[(4-hydroxyphenyl)methyl]-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6-one 
• 1448820-04-9 5-(4-hydroxybenzyl)-3-ethyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one 
• 1448820-13-0 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-(4-hydroxybenzyl)imidazol-5(4H)-one 

Relevant articles and documents

Step-Up Synthesis of Periodic Mesoporous Organosilicas with a Tyrosine Framework and Performance in Horseradish Peroxidase Immobilization

New amino-acid-bridged periodic mesoporous organosilicas (PMOs) were constructed by hydrolysis and condensation reactions under acid conditions in the presence of a template. The tyrosine bissilylated organic precursor (TBOS) was first prepared through a multistep reaction by using tyrosine (a natural amino acid) as the starting material. PMOs with the tyrosine framework (Tyr-PMOs) were constructed by simultaneously using TBOS and tetraethoxysilane as complex silicon sources in the condensation process. All the Tyr-PMOs materials were characterized by XRD, FTIR spectroscopy, N2 adsorption–desorption, TEM, SEM, and solid-state 29Si NMR spectroscopy to confirm the structure. The horseradish peroxidase (HRP) enzyme was first immobilized on these new Tyr-PMOs materials. Optimal conditions for enzyme adsorption included a temperature of 40 °C, a time of 8 h, and a pH value of 7. Furthermore, the novel Tyr-PMOs materials could store HRP for approximately 40 days and maintained the enzymatic activity, and the Tyr-PMOs–10 % HRP with the best immobilization effect could be reused at least eight times.

Synthesis of novel 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-ones and 1,2,4-triazin-6(5H)-ones from optically active α-aminocarboxylic acid hydrazides

New derivatives of 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-one and 1,2,4-triazin-6(5H)-one were synthesized via reactions of optically active α-aminocarboxylic acid hydrazides and triethyl orthoesters in xylene. The factors influencing the formation of the unexpected five-membered products and attempts to elucidate the mechanism are discussed.