76647-67-1

Basic information

• Product Name: (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID
• Synonyms: beta-amino-alpha-hydroxy-,(r*,s*)-benzenebutanoicaci;beta-amino-alpha-hydroxybenzenebutanoicacid;(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOIC ACID;Benzenebutanoic acid, beta-amino-alpha-hydroxy-, (R*,S*)-
• CAS NO: 76647-67-1
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 76647-67-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 428.5 °C at 760 mmHg
• Flash Point: 213 °C
• Appearance: /
• Density: 1.285 g/cm³
• Vapor Pressure: 4.17E-08mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID(76647-67-1)
• EPA Substance Registry System: (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID(76647-67-1)

Safety Data

• Hazardous Substances Data: 76647-67-1(Hazardous Substances Data)

Usage

General Description

(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyric acid is a chemical compound with the molecular formula C10H13NO3. It is a chiral amino acid derivative that contains an amino group and a hydroxyl group on a four-carbon chain with a phenyl group attached. It is an important intermediate in the synthesis of various pharmaceuticals and natural products, and it plays a role in the biosynthesis of certain peptides. (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID has potential applications in the development of new drugs and biologically active molecules due to its unique structural properties and functional groups. Additionally, it may have potential bioactive properties and is the subject of ongoing research in the fields of medicinal chemistry and chemical biology.

InChI:InChI=1/C10H13NO3/c11-8(9(12)10(13)14)6-7-4-2-1-3-5-7/h1-5,8-9,12H,6,11H2,(H,13,14)/t8-,9+/m0/s1

Upstream product

• 73845-40-6 methyl trans-2,3-epoxy-4-phenylbutanoate 
• 63158-17-8 methyl (E)-4-phenyl-2-butenoate 
• 136354-01-3 N-methoxycarbonyl-1-methoxy-2-phenylethylamine 
• 75443-87-7 methyl DL-erythro-3-amino-2-hydroxy-4-phenylbutanoate 
• 6540-96-1 2-benzyl-4-pentenoic acid 
• 501-52-0 3-Phenylpropionic acid 
• 73845-40-6 methyl cis-2,3-epoxy-4-phenylbutanoate 
• 34541-75-8 methyl (Z)-4-phenyl-2-butenoate 
• 75414-66-3 methyl threo-3-hydroxy-2-tosyloxy-4-phenylbutanoate 
• 75414-69-6 methyl threo-2,3-dihydroxy-4-phenylbutanoate 
• 37779-49-0 methyl 3-oxo-4-phenylbutanoate 
• 73845-38-2 methyl 4-phenylbut-2-ynoate 
• 75523-28-3 5-benzyl-1,2-dihydropyrazol-3-one 
• 75443-87-7 methyl DL-threo-3-amino-2-hydroxy-4-phenylbutanoate 

Relevant articles and documents

N -Boc amines to oxazolidinones via Pd(II)/bis-sulfoxide/br?nsted acid Co-catalyzed allylic C-H oxidation

A Pd(II)/bis-sulfoxide/Br?nsted acid catalyzed allylic C-H oxidation reaction for the synthesis of oxazolidinones from simple N-Boc amines is reported. A range of oxazolidinones are furnished in good yields (avg 63%) and excellent diastereoselectivities (avg 15:1) to furnish products regioisomeric from those previously obtained using allylic C-H amination reactions. Mechanistic studies suggest the role of the phosphoric acid is to furnish a Pd(II)bis-sulfoxide phosphate catalyst that promotes allylic C-H cleavage and π-allylPd functionalization with a weak, aprotic oxygen nucleophile and to assist in catalyst regeneration.

Regio- and stereo-specific synthesis of threo-3-amino-2-hydroxy-acids, novel amino-acids contained in aminopeptidase inhibitors of microbial origin.

-