76648-01-6

Basic information

• Product Name: Cefbuperazone sodium
• Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R,3S)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-3-hydroxy-1-oxobutyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-3-hydroxy-1-oxobutyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6R-[6α,7α,7(2R*,3S*)]]-;T 1982;Cefbuperazone sodium;Sodium (6R,7S)-7-[[(2R,3S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-3-hydroxybutanoyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(2-((2,3-dioxo-4-ethyl-1-piperazinyl)formamido)-3-hydroxybutyramido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, (6R-(6-alpha,7-alpha,7(2R*,3S*)))-;Cefbuperazone Acid
• CAS NO: 76648-01-6
• Molecular Formula: C22H28N9NaO9S2
• Molecular Weight: 649.63
• Mol File: 76648-01-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cefbuperazone sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Cefbuperazone sodium(76648-01-6)
• EPA Substance Registry System: Cefbuperazone sodium(76648-01-6)

Safety Data

• Hazardous Substances Data: 76648-01-6(Hazardous Substances Data)

Usage

Description

Cefbuperazone sodium, also known as TOMIPORAN or KEIPERAZON, is a β-lactamase resistant, third-generation cephalosporin antibiotic. It is characterized by its resistance to β-lactamase enzymes, which are produced by many bacteria to inactivate commonly used penicillins and cephalosporins. This resistance makes Cefbuperazone sodium effective against a broad range of bacteria, including those that have developed resistance to other antibiotics. Additionally, it has a serum half-life of approximately 1.5 hours, which allows for effective and sustained therapeutic action.

Uses

Used in Pharmaceutical Industry:
Cefbuperazone sodium is used as an antibiotic for the treatment of various bacterial infections. Its resistance to β-lactamase enzymes allows it to be effective against a wide range of bacteria, including those that have developed resistance to other antibiotics. This makes it a valuable tool in the treatment of infections caused by both Gram-positive and Gram-negative bacteria.
Used in Hospital Settings:
In hospital settings, Cefbuperazone sodium is used to treat serious bacterial infections, particularly those that are resistant to other commonly used antibiotics. Its effectiveness against a broad spectrum of bacteria makes it a crucial component in the management of infections in patients with compromised immune systems or those who have been exposed to antibiotic-resistant bacteria.
Used in Research and Development:
Cefbuperazone sodium is also used in research and development for the study of antibiotic resistance and the development of new antimicrobial agents. Its unique properties and effectiveness against β-lactamase producing bacteria make it an important subject for research aimed at understanding the mechanisms of antibiotic resistance and developing new strategies to combat it.

Originator

Topama (Japan)

InChI:InChI=1/C22H29N9O9S2.Na/c1-5-29-6-7-30(16(35)15(29)34)20(39)23-12(10(2)32)14(33)24-22(40-4)18(38)31-13(17(36)37)11(8-41-19(22)31)9-42-21-25-26-27-28(21)3;/h10,12,19,32H,5-9H2,1-4H3,(H,23,39)(H,24,33)(H,36,37);/q;+1/p-1/t10-,12+,19+,22-;/m0./s1