766497-25-0

Basic information

• Product Name: N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine
• Synonyms: N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine
• CAS NO: 766497-25-0
• Molecular Weight: 465.624
• Mol File: 766497-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine(766497-25-0)
• EPA Substance Registry System: N-(3-trimethylsilyl-ethynyl)-6,7-bis(2-methoxyethoxy)-4-quinolyl-amine(766497-25-0)

Safety Data

• Hazardous Substances Data: 766497-25-0(Hazardous Substances Data)

Upstream product

• 950596-58-4 2-amino-4,5-bis-(2-methoxyethoxy)-benzonitrile 
• 144001-07-0 ((3-iodophenyl)ethynyl)trimethylsilane 

Downstream Products

• 183319-69-9 erlotinib hydrochloride 

Relevant articles and documents

distress Luo river for Nepal method for preparing and its derivatives

The invention discloses a preparation method of erlotinib and derivatives of erlotinib. The preparation method is characterized in that a compound II (when R2=H, the compound II is 6,7-(2-methoxyl-oxethyl)-quinoline-4-amine and a compound III (when R1=SiMe and R3=I, the compound III is 3- trimethylsilylacetylene-iodobenzene have a coupling reaction in an organic solvent under the actions of alkali, elementary substance copper and/or copper salt to obtain erlotinib and derivatives of erlotinib. The elementary substance copper and/or copper salt or palladium reagent is used as the base of the catalytic reaction, the N-(3-phenylacetylene)-6,7-di(2-methoxyl oxethyl)-4-quinoline amino acid salt (erlotinib, I) and the derivatives of erlotinib are prepared from midbody compoundS II and III. The preparation method has the advantages of use of low-price and easily available raw materials, , moderate reaction conditions, few side reaction, high yield and small environmental pollution and is applicable to the industrial production.