766557-02-2

Basic information

• Product Name: 6-CHLOROINDOLE-3-CARBOXYLIC ACID
• Synonyms: 6-CHLOROINDOLE-3-CARBOXYLIC ACID;1H-INDOLE-3-CARBOXYLICACID,6-CHLORO;6-chloro-3-indole acid
• CAS NO: 766557-02-2
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.6
• Product Categories: pharmacetical
• Mol File: 766557-02-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 449.7 °C at 760 mmHg
• Flash Point: 225.8 °C
• Appearance: /
• Density: 1.548
• Vapor Pressure: 7.12E-09mmHg at 25°C
• Refractive Index: 1.728
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-CHLOROINDOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROINDOLE-3-CARBOXYLIC ACID(766557-02-2)
• EPA Substance Registry System: 6-CHLOROINDOLE-3-CARBOXYLIC ACID(766557-02-2)

Safety Data

• Hazardous Substances Data: 766557-02-2(Hazardous Substances Data)

Usage

General Description

6-Chloroindole-3-carboxylic acid is an organic compound that represents a chlorinated derivative of indole-3-carboxylic acid. Its structural formula includes an indole ring; a bicyclic molecule made of a benzene ring fused to a pyrrole ring, with a chlorine atom attached to one carbon of the benzene ring, and a carboxylic acid group attached to another carbon. As a chemical reagent, this substance is often used in organic synthesis processes and in the production of various pharmaceuticals. However, despite its utilization in several areas, its potential toxicity, reactivity, as well as environmental effects are not extensively studied and therefore should be handled with care.

InChI:InChI=1/C9H6ClNO2/c10-5-1-2-6-7(9(12)13)4-11-8(6)3-5/h1-4,11H,(H,12,13)

Upstream product

• 1144460-70-7 6-chloro-1H-indole-3-carbaldehyde oxime 
• 194490-17-0 6-chloro-1H-indole-3-carbonitrile 
• 703-82-2 6-chloro-1H-indole-3-carbaldehyde 
• 676477-10-4 1-(6-chloro-1H-indol-3-yl)-2,2,2-trifluoroethan-1-one 
• 17422-33-2 6-chloroindole 

Downstream Products

• 920022-47-5 [6-chloro-1-[2-(dimethylamino)ethyl]indol-3-yl]-spiro[1H-isobenzofuran-3,4′-piperidine]-1′-yl-methanone 
• 921194-97-0 methyl 6-chloro-1H-indole-3-carboxylate 
• 17422-33-2 6-chloroindole 

Relevant articles and documents

Novel indole derivative and medicine containing the same (by machine translation)

[A] formation of Amyloid fibrils can be compounds, including therapeutic or prophylactic agent for neurodegenerative disease Amyloid fibrils formation inhibitor compound and of. (I) or its pharmaceutically acceptable compound represented by the formula [a] or a salt or solvate thereof includes the, Amyloid fibrils formation inhibitor. [R1 And R2 Each independently is H, an alkyl group, a cyano group or the like; R3 And R4 Each independently is H, or an alkyl group; R3 And R4 The, joint may form a ring; Ar1 And Ar2 The substituted or unsubstituted heteroaryl group are independently substituted/unsubstituted aryl groups /; X and Y are each independently a single bond, - (=O) - C etc., Z is O or CH2 ; N is an integer of 1 - 3][Drawing] no (by machine translation)

An investigation into the substituent effect of halogen atoms on the crystal structures of indole-3-carboxylic acid (ICA)

An investigation into the substituent effect of halogen atoms (F, Cl, Br) on the crystal structure of indole-3-carboxylic acid (ICA) was prepared in this work. The investigation was done through the aspect of crystal structure, intermolecular interactions and π...π stacking motifs with the assistance of infrared spectra, elemental analyses, NMR spectra, differential scanning calorimetry (DSC), thermogravimetric analyses (TGA) and hot stage microscopy (HSM) measurements. The results revealed that the different kinds of halogen atoms and the different substituted positions have a significant effect on the crystal structures, molecular π...π stacking motifs and the kinds of intermolecular interactions. We further correlated the melting points of the ICAs with the H-H, O-H and X-H (X = F, Cl, Br) interactions, and found a positive correlation between them.

BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG

The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.