76672-27-0

Basic information

• Product Name: 2(1H)-Quinoxalinone, 6-chloro-3-methyl-
• CAS NO: 76672-27-0
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.62
• Mol File: 76672-27-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinoxalinone, 6-chloro-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone, 6-chloro-3-methyl-(76672-27-0)
• EPA Substance Registry System: 2(1H)-Quinoxalinone, 6-chloro-3-methyl-(76672-27-0)

Safety Data

• Hazardous Substances Data: 76672-27-0(Hazardous Substances Data)

Usage

Compound type

Chemical compound, derivative of quinoxalinone

Structure

Bicyclic heteroaromatic organic compound with a chloro and a methyl group on the quinoxalinone ring

Usage

Building block in the synthesis of more complex organic molecules

Biological activity

Known to exhibit biological activity, of interest to pharmaceutical and medicinal chemistry research

Value

Valuable in various chemical and industrial applications due to its unique structural features and reactivity.

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 34797-69-8 p-chloro-o-nitroacetoacetanilide 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 76672-21-4 3,6-dichloro-2-methylquinoxaline 
• 76672-20-3 2,6-dichloro-2-methylquinoxaline 

Relevant articles and documents

Aqueous hydrofluoric acid catalyzed facile synthesis of 2,3,6-substituted quinoxalines

A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines in excellent yield is developed from θ-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures.

TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS

The present invention provides compounds of formula (Ia) and (Ib) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

The facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones

Facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones and these reaction mechanisms are described.The intramolecular cyclization reaction of 4'-substituted 2'-nitroacetoacetanilides in aqueous basic medium and the reduction of 6-substituted 2(1H)-quinoxalinone-4-oxide wit sodium borohydride or sodium hydrogensulfite were studied in detail