76678-64-3Relevant articles and documents
Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives
Lin, Hao,Bruhn, David F.,Maddox, Marcus M.,Singh, Aman P.,Lee, Richard E.,Sun, Dianqing
, p. 4070 - 4076 (2016)
Bacterial infections, caused by Mycobacterium tuberculosis and other problematic bacterial pathogens, continue to pose a significant threat to global public health. As such, new chemotype antibacterial agents are desperately needed to fuel and strengthen the antibacterial drug discovery and development pipeline. As part of our antibacterial research program to develop natural product-inspired new antibacterial agents, here we report synthesis, antibacterial evaluation, and structure–activity relationship studies of an extended chemical library of macrocyclic diarylheptanoids with diverse amine, amide, urea, and sulfonamide functionalities. Results of this study have produced macrocyclic geranylamine and 4-fluorophenethylamine substituted derivatives, exhibiting moderate to good activity against M. tuberculosis and selected Gram-positive bacterial pathogens.
Microwave-assisted synthesis of macrocycles via intramolecular and/or bimolecular Ullmann coupling
Shen, Li,Simmons, Charles J.,Sun, Dianqing
supporting information; experimental part, p. 4173 - 4178 (2012/08/28)
Microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling is described. Using the optimized conditions, a panel of macrocycles, with different substitution patterns, ring sizes, and linkers, has been successfully synthesized using microwave irradiation. To the best of our knowledge, this work represents the first examples of the microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling.
