7669-49-0

Basic information

• Product Name: 1-(4-NITROPHENYL)-3-PHENYL-2-THIOUREA
• Synonyms: 1-(4-NITROPHENYL)-3-PHENYL-2-THIOUREA
• CAS NO: 7669-49-0
• Molecular Formula: C₁₃H₁₁N₃O₂S
• Molecular Weight: 273.31
• Mol File: 7669-49-0.mol
• Article Data: 20

Chemical Properties

• Melting Point: 147-149°C
• Boiling Point: 427.3°C at 760 mmHg
• Flash Point: 212.2°C
• Appearance: /
• Density: 1.441g/cm³
• Vapor Pressure: 1.66E-07mmHg at 25°C
• Refractive Index: 1.771
• CAS DataBase Reference: 1-(4-NITROPHENYL)-3-PHENYL-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-NITROPHENYL)-3-PHENYL-2-THIOUREA(7669-49-0)
• EPA Substance Registry System: 1-(4-NITROPHENYL)-3-PHENYL-2-THIOUREA(7669-49-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7669-49-0(Hazardous Substances Data)

Usage

General Description

1-(4-Nitrophenyl)-3-phenyl-2-thiourea is a chemical compound with the formula C13H10N4O2S. It is a white to pale yellow crystalline powder with a molecular weight of 294.31 g/mol. 1-(4-NITROPHENYL)-3-PHENYL-2-THIOUREA is often used as an organic intermediate and in the synthesis of other chemicals. It exhibits a wide range of biological activities, including anti-inflammatory and antioxidant properties. Additionally, 1-(4-nitrophenyl)-3-phenyl-2-thiourea has been studied for its potential use as an antiparasitic agent. It should be handled and used with caution due to its potential harmful effects and toxicity.

InChI:InChI=1/C13H11N3O2S/c17-16(18)12-8-6-11(7-9-12)15-13(19)14-10-4-2-1-3-5-10/h1-9H,(H2,14,15,19)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 100-01-6 4-nitro-aniline 
• 785-81-9 4-nitro-N-(phenylmethylene)benzenamine 
• 2420-60-2 O-phenyl N-(4-nitrophenyl)thiocarbamate 
• 62-53-3 aniline 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 74439-49-9 C₁₄H₉N₃O₄S₂ 
• 75305-28-1 4-Nitro-N-[1-phenyl-1-(3-phenyl-thioureido)-meth-(Z)-ylidene]-benzenesulfonamide 
• 72995-55-2 2-tert-butyl-4-(4-nitro-phenyl)-3-phenyl-[1,2,4]oxadiazolidine-5-thione 

Downstream Products

• 7669-27-4 [3-(4-nitro-phenyl)-4-oxo-2-phenylimino-thiazolidin-5-yl]-acetic acid 
• 66695-94-1 1–(4-aminophenyl)-3-phenylthiourea 
• 636-04-4 N-Phenylbenzothioamide 
• 79942-41-9 N-(4-nitro-phenyl)-N',N''-diphenyl-guanidine 
• 859187-78-3 N,N'-bis-(4-nitro-phenyl)-N''-phenyl-guanidine 
• 100-01-6 4-nitro-aniline 
• 1010-53-3 3-phenyl-2,4-thiazolidinedione 
• 18440-30-7 N,N',N''-tris-(4-nitro-phenyl)-guanidine 
• 3111-89-5 O-ethyl-N-phenylthiocarbamate 
• 13806-75-2 N-(4-nitrophenyl)thiocarbamic acid O-ethyl ester 
• 102-08-9 N,N-diphenylthiourea 
• 114710-79-1 2-[(Z)-4-Nitro-phenylimino]-3-phenyl-thiazolidin-4-one 
• 1932-32-7 N-(4-nitrophenyl)-N'-phenylurea 
• 111022-26-5 1-(4-Nitro-phenyl)-3-phenyl-thiourea; compound with 2,3-dicyano-but-2-enedinitrile 

Relevant articles and documents

Selective binding and extraction of aqueous dihydrogen phosphate solutions via three-armed thiourea receptors

A series of neutral anion receptors with one to three thiourea arms were synthesized and their binding to tetrabutylammonium chloride, acetate, and dihydrogen phosphate salts in aqueous DMSO mixtures was examined. The three-armed thiourea host was found to strongly and selectively bind H2PO4- even in DMSO solutions containing up to 30% water. This enabled the dihydrogen phosphate salt to be extracted from water into chloroform in its dibasic form despite the high heat of the hydration of HPO42-.

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

Hydrogen-Bond Catalysis of Imine Exchange in Dynamic Covalent Systems

The reversibility of imine bonds has been exploited to great effect in the field of dynamic covalent chemistry, with applications such as preparation of functional systems, dynamic materials, molecular machines, and covalent organic frameworks. However, acid catalysis is commonly needed for efficient equilibration of imine mixtures. Herein, it is demonstrated that hydrogen bond donors such as thioureas and squaramides can catalyze the equilibration of dynamic imine systems under unprecedentedly mild conditions. Catalysis occurs in a range of solvents and in the presence of many sensitive additives, showing moderate to good rate accelerations for both imine metathesis and transimination with amines, hydrazines, and hydroxylamines. Furthermore, the catalyst proved simple to immobilize, introducing both reusability and extended control of the equilibration process.