767-81-7

Basic information

• Product Name: 6-methyl-1,2,4-benzenetriol
• Synonyms: 6-methyl-1,2,4-benzenetriol;3-Methyl-1,2,5-benzenetriol;2,3,5-trihydroxytoluene
• CAS NO: 767-81-7
• Molecular Formula: C₇H₈O₃
• Molecular Weight: 0
• Mol File: 767-81-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 313.1°C at 760 mmHg
• Flash Point: 160.6°C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 0.000276mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 6-methyl-1,2,4-benzenetriol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-1,2,4-benzenetriol(767-81-7)
• EPA Substance Registry System: 6-methyl-1,2,4-benzenetriol(767-81-7)

Safety Data

• Hazardous Substances Data: 767-81-7(Hazardous Substances Data)

Usage

General Description

6-methyl-1,2,4-benzenetriol is a notable organic chemical compound that belongs to the class of phenols, specifically the class of benzenoids carrying three hydroxy groups and a methyl group. These groups are attached to the benzene ring, which is a crucial constituent of the compound. Generally recognized for its antioxidants properties, the 6-methyl-1,2,4-benzenetriol is known to play a significant role in various biological and chemical processes. However, much akin to other chemicals, this compound needs precise handling and appropriate safety measures considering its potential toxicity and reactivity. Depending on its concentration, exposure to this compound may lead to a range of safety and health hazards.

InChI:InChI=1/C7H8O3/c1-4-2-5(8)3-6(9)7(4)10/h2-3,8-10H,1H3

Upstream product

• 36776-43-9 (((5-methyl-1,3-phenylene)bis(oxy))bis(methylene))dibenzene 
• 28814-66-6 2-methyl-6-methoxybenzene-1,4-diol 
• 2896-67-5 2-methyl-6-methoxyphenol 
• 611-68-7 2-methoxy-6-methyl-1,4-benzoquinone 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 39803-51-5 2,4-bis-(benzyloxy)-6-methylbenzaldehyde 
• 7732-18-5 water 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 487-69-4 2,4-dihydroxy-6-methylbenzaldehyde 
• 7722-84-1 dihydrogen peroxide 
• 286364-90-7 2,4-Dibenzyloxy-1-hydroxy-6-methylbenzene 
• 38790-14-6 1,2,5-trimethoxy-3-methylbenzene 
• 2446-75-5 2-hydroxy-6-methyl-[1,4]benzoquinone 
• 504-15-4 orcinol 

Downstream Products

• 70265-69-9 6,7-dihydroxy-2,2,5-trimethyl-4-chromanone 
• 176181-82-1 echinotinctone 
• 27613-31-6 2,4,5-trihydroxy-6-methylbenzoic acid 
• 16275-95-9 2,3,6-trihydroxy-p-toluic acid methyl ester 
• 857000-89-6 3,4,6-triacetoxy-2-methyl-benzaldehyde 
• 19104-05-3 3,4,6-trihydroxy-2-methyl-benzoic acid methyl ester 

Relevant articles and documents

Synthesis of Echinotinctone, A Fungal Fluorone Pigment

Echinotinctone (3) is formed by acid-catalyzed condensation of 1,2,4-trihydroxytoluene (1) with orcylaldehyde (2), a reaction mimicking the probable biosynthesis. A more efficient stepwise synthesis proceeds via the benzophenone intermediate 11, which can be converted to 2,6-dihydroxy-1,8-dimethyl-3H-xanthenn-3-one (3) by LiAlH4 reduction and subsequent acid-catalyzed ring closure.

NOVEL AND SELECTIVE SYNTHESES OF NEW ANALOGUES OF PRECOCENE-2 AND PRECOCENE-3 CONTAINING 5-METHYL- OR 8-METYL-SUBSTITUENTS

New analogues of precocene-2 and precocene-3 containing 5-methyl- or 8-methyl-substituents have been synthesised in good yields utilising regioselective O-alkylation of 6,7-dihydroxy-2,2,5-trimethyl-4-chromanone and 6,7-dihydroxy-2,2,8-trimethyl-4-chromanone as the key step.