76746-56-0

Basic information

• Product Name: ISOCOLUMBIN
• Synonyms: 2,6-Di-O-galloyl-1,5-anhydro-D-glucitol;Acertannin;Cha Tiao Qi Su A
• CAS NO: 76746-56-0
• Molecular Formula: C₂₀H₂₀O₁₃
• Molecular Weight: 468.36
• Product Categories: Miscellaneous Natural Products
• Mol File: 76746-56-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 898.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.85±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C
• PKA: 7.81±0.25(Predicted)
• CAS DataBase Reference: ISOCOLUMBIN(CAS DataBase Reference)
• NIST Chemistry Reference: ISOCOLUMBIN(76746-56-0)
• EPA Substance Registry System: ISOCOLUMBIN(76746-56-0)

Safety Data

• Hazardous Substances Data: 76746-56-0(Hazardous Substances Data)

Usage

General Description

Isocolumbin is a chemical compound found in a variety of plant species including Mahonia aquifolium and Corydalis yanhusuo. It belongs to the group of isoquinoline alkaloids and has been studied for its potential therapeutic effects. Research has shown that isocolumbin possesses anti-inflammatory, analgesic, and antimicrobial properties. It has also been found to have potential in the treatment of certain types of cancer. Isocolumbin has attracted interest for its potential use in traditional medicine and as a natural alternative for pharmaceutical drugs. Further research is needed to fully understand the pharmacological properties and potential applications of this chemical compound.

Downstream Products

• 476-66-4 ellagic acid 

Relevant articles and documents

Synthesis and comparative structure-activity study of carbohydrate-based phenolic compounds as α-glucosidase inhibitors and antioxidants

Twenty-one natural and unnatural phenolic compounds containing a carbohydrate moiety were synthesized and their structure-activity relationship (SAR) was evaluated for α-glucosidase inhibition and antioxidative activity. Varying the position of the galloyl unit on the 1,5-anhydro -D-glucitol (1,5-AG) core resulted in changes in the α-glucosidase inhibitory activity and notably, particularly strong activity was demonstrated when the galloyl unit was present at the C-2 position. Furthermore, increasing the number of the galloyl units significantly affected the α-glucosidase inhibition, and 2,3,4,6-tetra-galloyl-1,5-AG (54) and 2,3,4,6-tetra-galloyl-d-glucopyranose (61) exhibited excellent activities, which were more than 13-fold higher than the α-glucosidase inhibitory activity of acertannin (37). Moreover, a comparative structure-activity study suggested that a hemiacetal hydroxyl functionality in the carbohydrate core and a biaryl bond of the 4,6-O-hexahydroxydiphenoyl (HHDP) group, which are components of ellagitannins including tellimagrandin I, are not necessary for the α-glucosidase inhibitory activity. Lastly, the antioxidant activity increased proportionally with the number of galloyl units.