767567-84-0

Basic information

• Product Name: 2,6-DIMETHYL-3-NITROPYRIDINE
• CAS NO: 767567-84-0
• Molecular Formula: C7H8N2O2
• Molecular Weight: 0
• Mol File: 767567-84-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-DIMETHYL-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYL-3-NITROPYRIDINE(767567-84-0)
• EPA Substance Registry System: 2,6-DIMETHYL-3-NITROPYRIDINE(767567-84-0)

Safety Data

• Hazardous Substances Data: 767567-84-0(Hazardous Substances Data)

Usage

General Description

2,6-DIMETHYL-3-NITROPYRIDINE is a chemical compound with the molecular formula C7H8N2O2. It is a yellow to orange solid that is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemistry reactions. 2,6-DIMETHYL-3-NITROPYRIDINE is classified as a nitropyridine, which is a type of organic compound containing a pyridine ring with a nitro group attached to it. This chemical is known for its mild toxic properties, and safety precautions must be taken when handling and storing it.

Upstream product

• 97055-58-8 1,4-Dimethyl-3,5-dinitro-2-pyridone 
• 67-64-1 acetone 
• 97055-50-0 1,6-Dimethyl-3,5-dinitro-2-pyridone 
• 5860-71-9 2,6-dimethylpyridine-3-carboxylic acid 
• 108-48-5 2,6-dimethylpyridine 

Downstream Products

• 33883-98-6 6-methyl-3-nitro-2-trans-styryl-pyridine 
• 142078-39-5 3-nitro-2,6-distyrylpyridine 
• 24194-98-7 2-methyl-3-nitropyridine-6-carboxylic acid 
• 860362-36-3 5-methyl-2-phenyl-1H-pyrrolo[3,2-b]pyridine 
• 854018-76-1 2,5-dimethyl-1H-pyrrolo[3,2-b]pyridine 
• 855932-44-4 N-acetyl-sulfanilic acid-(2,6-dimethyl-[3]pyridylamide) 
• 42753-74-2 sulfanilic acid-(2,6-dimethyl-[3]pyridylamide) 
• 65156-92-5 2-(3-nitro-2-pyridinyl)-N,N-dimethyletheneamine 

Relevant articles and documents

Silver(I)-Promoted ipso-Nitration of Carboxylic Acids by Nitronium Tetrafluoroborate

A novel and efficient method for the regioselective nitration of a series of aliphatic and aromatic carboxylic acids to their corresponding nitro compounds using nitronium tetrafluoroborate and silver carbonate in dimethylacetamide has been described. This transformation is believed to proceed via the alkyl-silver or aryl-silver intermediate, which subsequently reacts with the nitronium ion to form nitro substances. Mild reaction conditions, tolerant of a broad range of functional groups, and formation of only the ipso-nitrated products are the key features of this methodology when compared to known methods for syntheses of nitroalkyls and nitroarenes.

Nucleophilic reaction upon electron-deficient pyridone derivatives. XIII. Regioselective synthesis of 2-substituted 3-nitropyridines by one-pot reaction of either 4- or 6-substituted 1-methyl-3,5-dinitro-2-pyridones with ketones and ammonia

A one-pot synthesis of 2-substituted 3- nitropyridines was developed by a ring transformation of 6- or 4-substituted 1-methyl-3,5-dinitro-2-pyridones (2 or 3) with ammonia and enamines derived from ketones. Some intermediates having a 2,6-diazabicyclo[3.3.1]nonane skeleton were isolated from reactions of 3. The ring transformation proceeds via an addition-addition-elimination-elimination mechanism. Few competitive isomeric by-products, 4-substituted 3-nitropyridines and 4-nitroanilines, were formed. All the 2 substrates showed good reactivity, but the 3 substrates having electron-withdrawing substituents were less reactive and selective. 1,4,6-Trimethyl-3,5-dinitro-2-pyridone did not give any products. The selectivity is interpreted in terms of differences of thermodynamic (main selection rule B) and kinetic stability (minor selection rule A) between the possible bicyclic intermediates which are expected to be formed via the mechanism.

REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED 3-NITROPYRIDINES BY ONE-POT REACTION OF EITHER 4- OR 6-SUBSTITUTED 1-METHYL-3,5-DINITRO-2-PYRIDONES WITH KETONES AND AMMONIA

Regioselective synthesis of 2-substituted 3-nitropyridines was achieved by one-pot reaction of either 4- or 6-substituted 1-methyl-3,5-dinitro-2-pyridones with ketones in the presence of ammonia.The selectivity is interpreted in terms of steric factor of substituent on the pyridone.