768-04-7

Basic information

• Product Name: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)
• Synonyms: Ethanone, 1-cyclohexyl-2-fluoro- (9CI);1-Cyclohexyl-2-fluoro-ethanone
• CAS NO: 768-04-7
• Molecular Formula: C₈H₁₃FO
• Molecular Weight: 144.1866232
• Product Categories: ACETYLHALIDE
• Mol File: 768-04-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)(768-04-7)
• EPA Substance Registry System: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)(768-04-7)

Safety Data

• Hazardous Substances Data: 768-04-7(Hazardous Substances Data)

Upstream product

• 31151-40-3 2-cyclohexyl-1-diazo-2-ethanone 
• 13898-94-7 3-cyclohexyl-3-oxopropanoic acid 
• 56077-28-2 Bromomethyl cyclohexyl ketone 
• 503-20-8 fluoroacetonitrile 
• 931-50-0 cyclohexylmagnesium bromide 

Downstream Products

• 1415314-86-1 C₁₂H₁₉FO₂ 
• 1415314-91-8 C₁₀H₁₇FO 
• 1415315-15-9 C₁₂H₂₁F 
• 75600-48-5 (Z)-1-cyclohexyl-1,2-difluoroethylene 
• 75600-51-0 cis-1-cyclohexyl-1,2-difluoro-1,2-epoxyethane 
• 67835-09-0 1,3-Dicyclohexyl-2,4-difluoro-3-dihydrobutenon-⁽²⁾ 
• 75600-45-2 1-cyclohexyl-1,1,2-trifluoroethane 

Relevant articles and documents

Decarboxylative fluorination of β-Ketoacids with N-fluorobenzenesulfonimide (NFSI) for the synthesis of α-fluoroketones: Substrate scope and mechanistic investigation

Cesium carbonate (Cs2CO3)-mediated decarboxylative fluorination of β-ketoacids using NFSI in the MeCN/H2O mixed solvent system affords α-fluoroketones with a broad scope. Both electron-rich and electron-deficient α-non-substituted β-ketoacids are amenable to this protocol. The mechanistic study indicates that the reaction proceeds through electrophilic fluorination followed by decarboxylation, which is different from the decarboxylative fluorination of normal carboxylic acids.

Synthesis of α-Fluoromethyl Ketones via Allene Epoxides

α-Fluoromethyl ketones are formed via the reaction of allene epoxides with tetrabutylammonium fluoride trihydrate (TBAF*3H2O) in THF.