768-41-2

Basic information

• Product Name: 2-azatricyclo[3.3.1.13,7 ]decane
• Synonyms: 2-azatricyclo[3.3.1.13,7 ]decane
• CAS NO: 768-41-2
• Molecular Weight: 137.225
• Mol File: 768-41-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 224-227 °C(bomb tube)
• Boiling Point: 214.5±8.0 °C(Predicted)
• Density: 1.012±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-azatricyclo[3.3.1.13,7 ]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-azatricyclo[3.3.1.13,7 ]decane(768-41-2)
• EPA Substance Registry System: 2-azatricyclo[3.3.1.13,7 ]decane(768-41-2)

Safety Data

• Hazardous Substances Data: 768-41-2(Hazardous Substances Data)

Usage

Main properties

1. Chemical compound: 2-azatricyclo[3.3.1.13,7]decane
2. Also known as: azabicyclo[3.3.1]nonane
3. Part of: bicyclic bridged heterocycles group
4. Tricyclic system with a nitrogen atom and a bridging methylene group

Specific content

1. Commonly used as: building block in organic chemistry and medicinal chemistry
2. Applications: synthesis of pharmaceuticals and biologically active molecules
3. Potential applications in: material science and as a ligand in metal coordination chemistry
4. Versatile and valuable: building block for multiple chemical processes and applications

Upstream product

• 3632-95-9 (1s,3s,5R,7S)-1-chloro-2-azaadamantane 
• 16473-11-3 bicyclo[3.3.1]nonane-2,6-dione 
• 13534-08-2 Bicyclo<3.3.1>nonadion-(2.6)-bis-(p-toluolsulfonylhydrazon) 
• 78127-55-6 2-Azaadamantane-anti-4,8-diol 
• 78127-62-5 exo-2,3-exo-6,7-diepoxybicyclo<3.3.1>nonane 
• 13534-07-1 Bicyclo<3.3.1>nona-2,6-diene 
• 78127-63-6 anti,anti-4,8-Dichloro-2-azaadamantane hydrochloride 
• 1155843-79-0 2-azatricyclo[3.3.1.1^3,7]decan-2-ol 
• 88537-12-6 3-endo-methoxycarbonylaminobicyclo<3.3.1>non-6-ene 
• 56820-19-0 bicyclo<3.3.1>non-6-ene-3-endo-carboxylic acid 
• 23014-71-3 4-oxotricyclo [3.3.1.1^{3, 7}]dec-2-yl methanesulfonate 
• 700-58-3 2-Adamantanone 
• 1274919-04-8 C₉H₁₄BrN 

Downstream Products

• 57625-08-8 2-azaadamantane-N-oxyl 
• 79191-41-6 N-benzyl-2-azatricyclo[3.3.1.13,7]decane 
• 1622872-44-9 C₁₇H₁₈F₃NO 
• 1622872-37-0 C₃₆H₄₂N₂O₄ 
• 1622872-59-6 C₄₆H₅₁N₃O₅ 
• 1622872-49-4 C₁₆H₁₉NO₂ 
• 1622401-42-6 benzyl(2-(2-azaadamantane-2-yl)-2-oxoethyl)carbamate 
• 1392473-63-0 (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-2-azaadamantane-2-carboxamide 
• 57625-08-8 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl 

Relevant articles and documents

C?H Activation from Iron(II)-Nitroxido Complexes

The reaction of nitroxyl radicals TEMPO (2,2′,6,6′-tetramethylpiperidinyloxyl) and AZADO (2-azaadamantane-N-oxyl) with an iron(I) synthon affords iron(II)-nitroxido complexes (ArL)Fe(κ1-TEMPO) and (ArL)Fe(κ2-N,O

COMPOUNDS CONTAINING AN ALICYCLIE STRUCTURE AND ANTI-TUMOR APPLICATION

This invention relates with anti-tumor activities of new compounds containing an adamantyl group or analogs thereof. The invention also relates with the medication applications of anti-tumor and other diseases by this kind of compounds with the combination of S, P, T structures containing adamantyl group and the formation of stereoisomer, tautomers, prodrug, pharmaceutically acceptable salts, complex salts or solvates to their anticancer application and anticancer agents, which have the following general formula:

Practical preparation methods for highly active azaadamantane-nitroxyl- radical-type oxidation catalysts

We have recently disclosed that a less hindered class of nitroxyl radicals, i.e., 2-azaadamantan-N-oxyl (AZADO), 1-Me-AZADO, and 9-azabicyclo[3.3.1]nonan- N-oxyl (ABNO), exhibit marked catalytic activity for the oxidation of alcohols with the aid of environmentally friendly oxidants, offering a green and sustainable option for current alcohol oxidation. Encouraged by their outstanding catalytic performance, we envisioned the development of scalable routes to these radicals that could be extended to the commercialization of these radicals for benchtop use as well as for industrial use as optional reagents that complement TEMPO, the flagship compound of stable nitroxyl radicals. We herein describe short and reproducible preparation methods for AZADO and 1-Me-AZADO, featuring an efficient construction of the 2-azaadamantane skeleton. 1 Introduction 2 1-Me-AZADO and AZADO: First-Generation Syntheses 3 Second-Generation Synthesis of 1-Me-AZADO 4 Synthetic Venture towards 2-Azaadamantane: Second-Generation Synthesis of AZADO 5 Conclusion. Georg Thieme Verlag Stuttgart.