76843-81-7

Basic information

• Product Name: erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid o-nitrobenzyl ester
• CAS NO: 76843-81-7
• Molecular Weight: 447.832
• Mol File: 76843-81-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid o-nitrobenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid o-nitrobenzyl ester(76843-81-7)
• EPA Substance Registry System: erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid o-nitrobenzyl ester(76843-81-7)

Safety Data

• Hazardous Substances Data: 76843-81-7(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 105933-67-3 N-benzyloxycarbonyl-α-(o-nitrobenzyl)-(Z)-α,β-dehydroglutamate 
• 104754-68-9 o-nitrobenzyl N-benzyloxycarbonyl-2-aminotetrahydro-5-oxo-2-furancarboxylate 
• 104754-51-0 N-benzyloxycarbonyl-2-aminotetrahydro-5-oxo-2-furancarboxylic acid 
• 88-72-2 1-methyl-2-nitrobenzene 
• 621-84-1 O-benzyl carbamate 
• 328-50-7 α-ketoglutaric acid 
• 104754-69-0 N-benzyloxycarbonyl-α-(o-nitrobenzyl)-(Z)-α,β-dehydroglutanic-γ-(N-p-methoxybenzyl)hydroxamic acid 
• 104754-70-3 erythro, threo-DL-N-benzyloxycarbonyl-α-amino-2-(p-methoxybenzyl)-3-oxo-5-isoxazolidineacetic acid o-nitrobenzyl ester 

Downstream Products

• 42228-92-2 erythro-DL-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid <(+/-)-AT-125> 
• 76843-83-9 erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid 

Relevant articles and documents

TOTAL SYNTHESIS OF ANTITUMOR AGENT AT-125, (αS,5S)-α-AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID

A short and efficient total synthesis of racemic AT-125 and its racemic threo isomer proceeds via an intramolecular Michael cyclization of a protected α,β-dehydroglutamic acid γ-hydroxamate.Separation of diastereomers and deprotection to racemic AT-125 followed by enzymatic resolution of the N-chloroacetamide with hog-kidney acylase provides the natural αS,5S isomer.