76874-79-8

Basic information

• Product Name: 2-AMINO-4-CHLORO-5-THIAZOLECARBALDEHYDE
• Synonyms: 2-AMINO-4-CHLORO-5-THIAZOLECARBALDEHYDE;2-AMINO-4-CHLOROTHIAZOLE-5-CARBALDEHYDE;2-AMINO-4-Chlorothiazloe-5-carbaldehyde;2-Amino-4-chloro-1,3-thiazole-5-carboxaldehyde;2-Amino-4-chlorothiazole-5-carboxaldehyde;Zinc02557657;2-Amino-4-chloro-1,3-thiazole-5-carboxaldehyde 98%;2-Amino-4-chloro-5-formyl-1,3-thiazole
• CAS NO: 76874-79-8
• Molecular Formula: C₄H₃ClN₂OS
• Molecular Weight: 162.6
• Product Categories: Thiazole
• Mol File: 76874-79-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 341.257 °C at 760 mmHg
• Flash Point: 160.187 °C
• Appearance: /
• Density: 1.659 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.717
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.39±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-CHLORO-5-THIAZOLECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-CHLORO-5-THIAZOLECARBALDEHYDE(76874-79-8)
• EPA Substance Registry System: 2-AMINO-4-CHLORO-5-THIAZOLECARBALDEHYDE(76874-79-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 76874-79-8(Hazardous Substances Data)

Usage

General Description

2-Amino-4-Chloro-5-Thiazolecarbaldehyde is a chemical compound characterized by its incorporation of chlorine, nitrogen, sulfur, hydrogen, and carbon atoms. Given the specificity of its structure and composition, it is especially relevant in fields like chemistry, pharmacology, and material sciences. Its roles in these areas could involve being used as an analytical reagent, a foundation for synthesizing other substances, or even possibly as an intermediary in the formulation of specific pharmaceutical drugs. Just like any other chemical substance, appropriate precautions must be taken when handling 2-Amino-4-Chloro-5-Thiazolecarbaldehyde due to potential physical or health hazards. Beyond these elements, however, more specific details about the properties and functions of 2-Amino-4-Chloro-5-Thiazolecarbaldehyde are limited, owing to its specialized nature and use.

InChI:InChI=1/C4H3ClN2OS/c5-3-2(1-8)9-4(6)7-3/h1H,(H2,6,7)

Upstream product

• 21295-50-1 phosphorus (III) oxychloride 
• 2192-06-5 2-Amino-4-thiazolinone hydrochloride 
• 68-12-2 N,N-dimethyl-formamide 
• 17356-08-0 thiourea 
• 79-11-8 chloroacetic acid 

Downstream Products

• 179749-68-9 N-(5-(bis(2-hydroxyethyl)amino)-2-((4-chloro-5-formylthiazol-2-yl)diazenyl)-4-methoxyphenyl)acetamide 
• 1020730-89-5 4-chloro-2-((E)-{4-[ethyl(2-hydroxyethyl)amino]phenyl}-diazenyl)-1,3-thiazole-5-carbaldehyde 
• 957051-08-0 N-(4-chloro-5-formylthiazol-2-yl)benzamide 
• 388594-31-8 (4-chloro-5-formylthiazol-2-yl)carbamic acid tert-butyl ester 
• 177159-58-9 2-<4-phenylazo>-4-chlorothiazole-5-carbaldehyde 
• 208331-37-7 4-chloro-2-<4-phenylazo>thiazole-5-carbaldehyde 
• 106610-93-9 4-chloro-2-<4-(diethylamino)phenylazo>thiazole-5-carbaldehyde 

Relevant articles and documents

Tetramethylammonium Fluoride Tetrahydrate for SNAr Fluorination of 4-Chlorothiazoles at a Production Scale

This article describes the use of tetramethylammonium fluoride tetrahydrate (TMAF·4H2O) for the large-scale preparation of a challenging 4-fluorothiazole. Commercially available TMAF·4H2O was procured on a large scale and rigorously dried by distillation with isopropyl alcohol and then dimethylformamide at elevated temperature. This method of drying provided anhydrous TMAF [TMAF (anh)] containing a 45.1 kg scale at 95-100 °C to produce 36.8 kg of 4-fluorothiazole 1b.

Preparation of 2-amino-5-formyl-4-halothiazoles

A process for the preparation of 2-amino-5-formyl-4-halothiazoles by reaction, in a first stage, of thiourea with chloroacetic or bromoacetic acid in the presence of an N,N-disubstituted formamide, followed by treatment of the reaction mixture with a phosphoric trihalide and then with water in the presence of a base.