769172-81-8

Basic information

• Product Name: 6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline;(S)-6,7-DiMethoxy-1-(4-(trifluoroMethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 769172-81-8
• Molecular Formula: C₂₀H₂₂F₃NO₂
• Molecular Weight: 365
• Mol File: 769172-81-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 443.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.170
• Storage Temp.: 2-8°C
• PKA: 8.85±0.40(Predicted)
• CAS DataBase Reference: 6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline(769172-81-8)
• EPA Substance Registry System: 6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline(769172-81-8)

Safety Data

• Hazardous Substances Data: 769172-81-8(Hazardous Substances Data)

Usage

General Description

6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline is a chemical compound with a complex molecular structure. It is a tetrahydroisoquinoline derivative with two methoxy groups and a trifluoromethylphenylethyl group attached to the nitrogen atom. 6,7-Dimethoxy-1(S)-[2-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydroisoquinoline has potential pharmaceutical applications due to its structural resemblance to dopamine antagonists and its affinity for dopamine receptors. It may also have potential as a ligand in drug development and research. However, further research is needed to fully understand its properties, potential uses, and any potential risks associated with its use.

Upstream product

• 132283-68-2 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde 
• 1609564-22-8 (S)-tert-butyl-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1609564-20-6 (S)-tert-butyl 1-(2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 884337-44-4 (S)-1-allyl-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 181220-97-3 (S)-1-allyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1415385-75-9 (S)-1-allyl-2-((R)-tert-butylsulfinyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1415385-74-8 (R)-N-((S)-1-(2-(2-chloroethyl)-4,5-dimethoxyphenyl)but-3-enyl)-2-methylpropane-2-sulfinamide 
• 769172-66-9 N-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-(4-trifluoromethyl-phenyl)-propionamide 
• 1169801-32-4 6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-isoquinoline methanesulfonic acid salt 
• 324076-69-9 6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydroiso-quinoline 
• 4721-98-6 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 1169801-28-8 (S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline acetate 

Downstream Products

• 1169801-28-8 (S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline acetate 
• 871224-64-5 almorexant 
• 769172-65-8 (R)-2-{(S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-3,4-dihydro-1H-isoquinolin-2-yl}-2-phenyl-acetamide 

Relevant articles and documents

Stereoselective total synthesis of almorexant

A highly stereoselective synthesis of almorexant has been achieved using (R)-tert-butanesulfinamide as a chiral source. The chiral tetrahydroisoquinoline core was constructed through allylation of chiral N-sulfinyl imine followed by ring closure of the se

METHOD FOR OBTAINING AN OPTICALLY PURE 1,2,3,4 TETRAHYDRO-ISOQUINOLINE DERIVATIVE

The invention relates to a method for obtaining enantiomerically enriched 6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline from a mixture of (R)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline and (S)-6,7-dimethoxy-1-[2-(4-trifluoromethyl-phenyl)-ethyl]-1,2,3,4-tetrahydro-isoquinoline.

PROCESS FOR THE PREPARATION OF AN ENANTIOMERIC TRISUBSTITUTED 3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE

The present invention relates to a process for the preparation of the compound of formula (7) which process comprises the hydrogenation of the compound of formula (4) using bis[chloro-1,5-cyclooctadiene-iridium], (S)-i-dicyclohexylphosphino-2-[(S)-α-(dime