7697-25-8

Basic information

• Product Name: 2-CHLORO-4-METHYLBENZOIC ACID
• Synonyms: 4-Carboxy-3-chlorotoluene, 2-Chloro-p-toluic acid;Benzoicacid, 2-chloro-4-methyl-
• CAS NO: 7697-25-8
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.5943
• Mol File: 7697-25-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 195 °C
• Boiling Point: 303.5 °C at 760 mmHg
• Flash Point: 137.4 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 0.000407mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.19±0.25(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-METHYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHYLBENZOIC ACID(7697-25-8)
• EPA Substance Registry System: 2-CHLORO-4-METHYLBENZOIC ACID(7697-25-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 7697-25-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methylbenzoic acid is a chemical compound with the molecular formula C8H7ClO2. It is a derivative of benzoic acid with a chlorine atom and a methyl group attached to the benzene ring. 2-CHLORO-4-METHYLBENZOIC ACID is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. 2-Chloro-4-methylbenzoic acid is a white crystalline solid with a slightly aromatic odor. It is soluble in organic solvents such as ethanol and acetone, but only slightly soluble in water. 2-CHLORO-4-METHYLBENZOIC ACID should be handled and stored with appropriate safety precautions due to its potential to cause skin and eye irritation.

InChI:InChI=1/C8H7ClO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,1H3,(H,10,11)

Upstream product

• 21423-84-7 2-chloro-4-methylbenzonitrile 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 4395-80-6 2-chloro-1-isopropyl-4-methyl-benzene 
• 7697-37-2 nitric acid 
• 95-72-7 2-chloro-1,4-dimethyl-benzene 

Downstream Products

• 1967-31-3 2-chloroterephthalic acid 
• 21900-53-8 2-chloro-4-methyl-benzoyl chloride 
• 200265-71-0 2-chloro-4-methyl-3,5-dinitro-benzoic acid 
• 101580-96-5 2-chloro-4-methyl-5-nitrobenzoic acid 
• 144463-72-9 allyl 2-phenoxy-4-methylbenzoate 
• 290820-38-1 2-chloro-4-(bromomethyl)benzoic acid 
• 99-94-5 p-Toluic acid 
• 143572-60-5 methyl 4-(bromomethyl)-2-chlorobenzoate 
• 1381846-08-7 N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide 
• 1381846-29-2 2-chloro-5-(isobutyramidomethyl)-4-methylbenzoic acid 

Relevant articles and documents

Benzohydroxamic acids as potent and selective anti-HCV agents

A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations. The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV.

Regiospecific chlorination of xylenes using K-10 montmorrillonite clay

Regiospecific chlorination of xylenes has been developed by employing NCS as a reagent and K-10 montmorrillonite clay as a solid support. Copyright Taylor & Francis Group, LLC.

Substituted alkylidene imidazoles

This disclosure relates to a class of novel substituted alkylidene imidazole derivatives and pharmaceutically acceptable salts thereof. The disclosure further describes pharmaceutical compositions containing such compounds and to the use of such compounds