76973-37-0Relevant articles and documents
Synthesis of pyranopyrazoles using isonicotinic acid as a dual and biological organocatalyst
Zolfigol, Mohammad Ali,Tavasoli, Mahsa,Moosavi-Zare, Ahmad Reza,Moosavi, Parvin,Kruger, Hendrik Gerhardus,Shiri, Morteza,Khakyzadeh, Vahid
, p. 25681 - 25685 (2013)
In this study, a green, simple and efficient method for the preparation of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c] pyrazoles by means of a one-pot four component condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate is reported. The reaction utilizes isonicotinic acid as a dual and biological organocatalyst at 85 °C under solvent-free conditions.