769944-85-6

Basic information

• Product Name: (2S)-2-(4-bromophenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester
• Synonyms: (2S)-2-(4-bromophenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester
• CAS NO: 769944-85-6
• Molecular Weight: 441.365
• Mol File: 769944-85-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-2-(4-bromophenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(4-bromophenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester(769944-85-6)
• EPA Substance Registry System: (2S)-2-(4-bromophenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester(769944-85-6)

Safety Data

• Hazardous Substances Data: 769944-85-6(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 62566-68-1 (R)-2-(4-bromophenyl)oxirane 
• 96855-38-8 (R)?2?bromo?1?(4′?bromophenyl)ethanol 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 769944-65-2 (S)-1,4-di(t-butoxycarbonyl)-2-(4'-methoxybiphen-4-yl)piperazine 
• 769944-57-2 (S)-1,4-di-(t-butoxycarbonyl)-2-(4-((R)-3-hydroxypyrrolidino)phenyl)piperazine 
• 881919-93-3 (2S)-2-(4-piperidin-1-yl-phenyl)-piperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 769944-63-0 (S)-1,4-di(t-butoxycarbonyl)-2-(4-(N,N-dimethylamino)phenyl)piperazine 

Relevant articles and documents

Asymmetric synthesis of 2-arylpiperazines

An asymmetric synthesis of 2-arylpiperazines starting from phenacyl bromides, a variety of which are easily available, has been established. The synthesis features a CBS reduction of phenacyl bromide to provide optically enriched compounds, an SN2 reaction of 1,2,3-oxathiazolidine 2-oxides with an azide anion with invert of configuration, and construction of the piperazine ring via reduction of piperazine-2,3-diones.