769961-84-4Relevant articles and documents
Cumyl: A better N-protecting group of α-diazo acetamides for intramolecular C-H insertion reaction and its application in the synthesis of pregabalin and 3-benzyloxy pyrrolidine
Chen, Zhenliang,Chen, Zhiyong,Jiang, Yaozhong,Hu, Wenhao
, p. 1763 - 1764 (2004)
Via intramolecular C-H insertion of N-cumyl α-diazo acetamides, γ-lactams were efficiently synthesized with excellent regioselectivity. A concise route for the preparation of pregabalin (79% overall yield) and 3-benzyloxy pyrrolidine (21% overall yield) were reported.